Document Detail

Molecular mechanisms of ischemic neuronal injury.
MedLine Citation:
PMID:  11054204     Owner:  NLM     Status:  MEDLINE    
Brain ischemia triggers a complex cascade of molecular events that unfolds over hours to days. Identified mechanisms of postischemic neuronal injury include altered Ca(2+) homeostasis, free radical formation, mitochondrial dysfunction, protease activation, altered gene expression, and inflammation. Although many of these events are well characterized, our understanding of how they are integrated into the causal pathways of postischemic neuronal death remains incomplete. The primary goal of this review is to provide an overview of molecular injury mechanisms currently believed to be involved in postischemic neuronal death specifically highlighting their time course and potential interactions.
R W Neumar
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annals of emergency medicine     Volume:  36     ISSN:  0196-0644     ISO Abbreviation:  Ann Emerg Med     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2000-12-27     Completed Date:  2000-12-27     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8002646     Medline TA:  Ann Emerg Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  483-506     Citation Subset:  AIM; IM    
Department of Emergency Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19107-4283, USA.
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MeSH Terms
Brain Ischemia / classification,  genetics*,  metabolism*,  pathology
Endopeptidases / metabolism
Free Radicals / metabolism
Gene Expression
Mitochondria / physiology
Reg. No./Substance:
0/Free Radicals; EC 3.4.-/Endopeptidases

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