| Molecular mechanisms of ischemic neuronal injury. | |
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MedLine Citation:
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PMID: 11054204 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Brain ischemia triggers a complex cascade of molecular events that unfolds over hours to days. Identified mechanisms of postischemic neuronal injury include altered Ca(2+) homeostasis, free radical formation, mitochondrial dysfunction, protease activation, altered gene expression, and inflammation. Although many of these events are well characterized, our understanding of how they are integrated into the causal pathways of postischemic neuronal death remains incomplete. The primary goal of this review is to provide an overview of molecular injury mechanisms currently believed to be involved in postischemic neuronal death specifically highlighting their time course and potential interactions. |
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Authors:
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R W Neumar |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Annals of emergency medicine Volume: 36 ISSN: 0196-0644 ISO Abbreviation: Ann Emerg Med Publication Date: 2000 Nov |
Date Detail:
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Created Date: 2000-12-27 Completed Date: 2000-12-27 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8002646 Medline TA: Ann Emerg Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 483-506 Citation Subset: AIM; IM |
Affiliation:
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Department of Emergency Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19107-4283, USA. rneumar@mail.med.upenn.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis Brain Ischemia / classification, genetics*, metabolism*, pathology Endopeptidases / metabolism Free Radicals / metabolism Gene Expression Homeostasis Humans Mitochondria / physiology Necrosis |
| Chemical | |
Reg. No./Substance:
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0/Free Radicals; EC 3.4.-/Endopeptidases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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