Document Detail


Molecular mechanisms of in-stent restenosis and approach to therapy with eluting stents.
MedLine Citation:
PMID:  12732447     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Restenosis is the principal drawback of percutaneous coronary procedures. Until now, the only widely accepted way to reduce restenosis rate has been the stent. However, clinical restenosis still represents the major limitation of this technology. This article summarizes recent laboratory and clinical investigations concerning the mechanisms responsible for the transmission of mitogenic signals from plasma membrane to the nucleus in vascular smooth muscle cells that determine neointima formation after stent deployment. Recent experimental data on the impact of diabetes and physical exercise on restenosis also is reviewed. Finally, the new concept of local drugs that elute directly to the site of vascular injury from coated stents and the available clinical results obtained with rapamycin or paclitaxel-eluting stents are discussed.
Authors:
Ciro Indolfi; Annalisa Mongiardo; Antonio Curcio; Daniele Torella
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Trends in cardiovascular medicine     Volume:  13     ISSN:  1050-1738     ISO Abbreviation:  Trends Cardiovasc. Med.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-05-06     Completed Date:  2003-09-04     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9108337     Medline TA:  Trends Cardiovasc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  142-8     Citation Subset:  IM    
Affiliation:
Division of Cardiology, Magna Graecia University, Catanzaro, Italy. indolfi@unicz.it
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MeSH Terms
Descriptor/Qualifier:
Angioplasty, Transluminal, Percutaneous Coronary
Animals
Blood Vessel Prosthesis Implantation
Coated Materials, Biocompatible / therapeutic use*
Coronary Restenosis / etiology*,  physiopathology,  therapy*
Humans
Muscle, Smooth, Vascular / cytology,  physiopathology
Signal Transduction / physiology
Stents*
Chemical
Reg. No./Substance:
0/Coated Materials, Biocompatible

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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