| Molecular mechanisms of in-stent restenosis and approach to therapy with eluting stents. | |
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MedLine Citation:
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PMID: 12732447 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Restenosis is the principal drawback of percutaneous coronary procedures. Until now, the only widely accepted way to reduce restenosis rate has been the stent. However, clinical restenosis still represents the major limitation of this technology. This article summarizes recent laboratory and clinical investigations concerning the mechanisms responsible for the transmission of mitogenic signals from plasma membrane to the nucleus in vascular smooth muscle cells that determine neointima formation after stent deployment. Recent experimental data on the impact of diabetes and physical exercise on restenosis also is reviewed. Finally, the new concept of local drugs that elute directly to the site of vascular injury from coated stents and the available clinical results obtained with rapamycin or paclitaxel-eluting stents are discussed. |
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Authors:
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Ciro Indolfi; Annalisa Mongiardo; Antonio Curcio; Daniele Torella |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Trends in cardiovascular medicine Volume: 13 ISSN: 1050-1738 ISO Abbreviation: Trends Cardiovasc. Med. Publication Date: 2003 May |
Date Detail:
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Created Date: 2003-05-06 Completed Date: 2003-09-04 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 9108337 Medline TA: Trends Cardiovasc Med Country: United States |
Other Details:
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Languages: eng Pagination: 142-8 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Magna Graecia University, Catanzaro, Italy. indolfi@unicz.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty, Transluminal, Percutaneous Coronary Animals Blood Vessel Prosthesis Implantation Coated Materials, Biocompatible / therapeutic use* Coronary Restenosis / etiology*, physiopathology, therapy* Humans Muscle, Smooth, Vascular / cytology, physiopathology Signal Transduction / physiology Stents* |
| Chemical | |
Reg. No./Substance:
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0/Coated Materials, Biocompatible |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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