Document Detail

Molecular mechanisms of glutamate receptor clustering at excitatory synapses.
MedLine Citation:
PMID:  9687358     Owner:  NLM     Status:  MEDLINE    
The targeting of AMPA- and NMDA-type glutamate receptors to synapses in the central nervous system is essential for efficient excitatory synaptic transmission. Recent studies have indicated that protein-protein interactions of these receptors with synaptic proteins that contain PDZ domains are crucial for receptor targeting. NMDA receptors have been found to bind to the PSD-95 family of proteins, whereas AMPA receptors interact with the PDZ-domain-containing protein GRIP (glutamate receptor interacting protein). PSD-95 and GRIP contain multiple PDZ domains as well as other protein-protein interaction motifs that help to form large macromolecular complexes that may be important for the formation and plasticity of synapses.
R J O'Brien; L F Lau; R L Huganir
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in neurobiology     Volume:  8     ISSN:  0959-4388     ISO Abbreviation:  Curr. Opin. Neurobiol.     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-10-21     Completed Date:  1998-10-21     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9111376     Medline TA:  Curr Opin Neurobiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  364-9     Citation Subset:  IM    
Howard Hughes Medical Institute, Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
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MeSH Terms
Cloning, Molecular
Ion Channel Gating / physiology*
Receptors, AMPA / genetics*,  metabolism
Receptors, N-Methyl-D-Aspartate / genetics*,  metabolism
Signal Transduction / physiology*
Synapses / chemistry*,  physiology
Reg. No./Substance:
0/Receptors, AMPA; 0/Receptors, N-Methyl-D-Aspartate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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