Document Detail


Molecular mechanisms of fMLP-induced superoxide generation and degranulation in mouse neutrophils.
MedLine Citation:
PMID:  23062771     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In this manuscript, involvement of PLD in fMLP-induced superoxide generation and degranulation were re-investigated using PLD(-/-) neutrophils, and the molecular mechanisms of these neutrophil functions were examined. Neither PLD1 nor PLD2 is involved in these fMLP-induced neutrophil functions. The results obtained in this study provide evidence that cPKC plays an important role in fMLP-induced superoxide generation. On the other hand, Ca(2+)-dependent signaling pathway and cPKC seem to be involved in degranulation.
Authors:
Yasunori Kanaho; Takanobu Sato; Tsunaki Hongu; Yuji Funakoshi
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-28
Journal Detail:
Title:  Advances in biological regulation     Volume:  -     ISSN:  2212-4934     ISO Abbreviation:  Adv Biol Regul     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-10-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101572336     Medline TA:  Adv Biol Regul     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Physiological Chemistry, Faculty of Medicine and Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tennodai, Ibaraki 305-8575, Japan. Electronic address: ykanaho@md.tsukuba.ac.jp.
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