Document Detail


Molecular mechanisms of external genitalia development.
MedLine Citation:
PMID:  22790208     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
External genitalia development occurs through a combination of hormone independent, hormone dependent, and endocrine pathways. Perturbation of these pathways can lead to abnormal external genitalia development. We review human and animal mechanisms of normal and abnormal external genitalia development, and we evaluate abnormal mechanisms that lead to hypospadias. We also discuss recent laboratory findings that further our understanding of animal models of hypospadias.
Authors:
Sarah D Blaschko; Gerald R Cunha; Laurence S Baskin
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2012-07-11
Journal Detail:
Title:  Differentiation; research in biological diversity     Volume:  84     ISSN:  1432-0436     ISO Abbreviation:  Differentiation     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-14     Completed Date:  2012-12-20     Revised Date:  2013-10-17    
Medline Journal Info:
Nlm Unique ID:  0401650     Medline TA:  Differentiation     Country:  England    
Other Details:
Languages:  eng     Pagination:  261-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 International Society of Differentiation. Published by Elsevier B.V. All rights reserved.
Affiliation:
University of California San Francisco, Department of Urology, 400 Parnassus Avenue, A610, San Francisco, CA 94143, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Female
Genes, Developmental
Genitalia / abnormalities,  embryology*
Gonadal Steroid Hormones / pharmacology,  physiology
Humans
Hypospadias / etiology*
Male
Pregnancy
Prenatal Exposure Delayed Effects / chemically induced
Sex Determination Processes / genetics,  physiology
Sex Differentiation / genetics*,  physiology
Grant Support
ID/Acronym/Agency:
R01 DK058105/DK/NIDDK NIH HHS; R01DK0581050/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Gonadal Steroid Hormones
Comments/Corrections

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