Document Detail

Molecular mechanisms of cranial neural crest cell migration and patterning in craniofacial development.
MedLine Citation:
PMID:  20663816     Owner:  NLM     Status:  MEDLINE    
During vertebrate craniofacial development, neural crest cells (NCCs) contribute much of the cartilage, bone and connective tissue that make up the developing head. Although the initial patterns of NCC segmentation and migration are conserved between species, the variety of vertebrate facial morphologies that exist indicates that a complex interplay occurs between intrinsic genetic NCC programs and extrinsic environmental signals during morphogenesis. Here, we review recent work that has begun to shed light on the molecular mechanisms that govern the spatiotemporal patterning of NCC-derived skeletal structures - advances that are central to understanding craniofacial development and its evolution.
Maryline Minoux; Filippo M Rijli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  137     ISSN:  1477-9129     ISO Abbreviation:  Development     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-28     Completed Date:  2010-08-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  England    
Other Details:
Languages:  eng     Pagination:  2605-21     Citation Subset:  IM    
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland.
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MeSH Terms
Body Patterning*
Cell Movement*
Gene Expression Regulation, Developmental
Head / embryology*
Neural Crest / cytology*,  embryology*,  metabolism
Signal Transduction

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