| Molecular mechanisms of cranial neural crest cell migration and patterning in craniofacial development. | |
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MedLine Citation:
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PMID: 20663816 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During vertebrate craniofacial development, neural crest cells (NCCs) contribute much of the cartilage, bone and connective tissue that make up the developing head. Although the initial patterns of NCC segmentation and migration are conserved between species, the variety of vertebrate facial morphologies that exist indicates that a complex interplay occurs between intrinsic genetic NCC programs and extrinsic environmental signals during morphogenesis. Here, we review recent work that has begun to shed light on the molecular mechanisms that govern the spatiotemporal patterning of NCC-derived skeletal structures - advances that are central to understanding craniofacial development and its evolution. |
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Authors:
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Maryline Minoux; Filippo M Rijli |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Development (Cambridge, England) Volume: 137 ISSN: 1477-9129 ISO Abbreviation: Development Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-28 Completed Date: 2010-08-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8701744 Medline TA: Development Country: England |
Other Details:
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Languages: eng Pagination: 2605-21 Citation Subset: IM |
Affiliation:
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Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Patterning* Cell Movement* Gene Expression Regulation, Developmental Head / embryology* Humans Neural Crest / cytology*, embryology*, metabolism Signal Transduction |
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