Document Detail


Molecular mechanisms by which hormones and cytokines regulate cell junction dynamics in the testis.
MedLine Citation:
PMID:  19273571     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hormones and cytokines are known to regulate cellular functions in all tissues including testis. These two groups of biomolecules exert a broad spectrum of effects on various aspects of spermatogenesis. Among them, one of the regulatory effects on spermatogenesis is to modulate cell junction restructuring between Sertoli cells and between Sertoli and germ cells in the seminiferous epithelium. The restructuring of cell junctions is crucial to enable the migration of germ cells along the seminiferous epithelium from the basement membrane towards the tubular lumen, and at the same time for their attachment to Sertoli cells for support. This review will summarize the recent findings that focus on the role of hormones (FSH and testosterone) and cytokines (transforming growth factor-betas and tumor necrosis factor-alpha) on cell junction restructuring in the testis and the molecular mechanisms.
Authors:
Wing-Yee Lui; Will M Lee
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-03-09
Journal Detail:
Title:  Journal of molecular endocrinology     Volume:  43     ISSN:  1479-6813     ISO Abbreviation:  J. Mol. Endocrinol.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-20     Completed Date:  2009-09-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8902617     Medline TA:  J Mol Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  43-51     Citation Subset:  IM    
Affiliation:
School of Biological Sciences, University of Hong Kong, Hong Kong, People's Republic of China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cytokines / metabolism*
Estrogens / metabolism
Follicle Stimulating Hormone / metabolism
Hormones / metabolism*
Intercellular Junctions / metabolism*
Male
Mice
Peptides / metabolism
Rats
Spermatogenesis*
Testis / metabolism*
Testosterone / metabolism
Transforming Growth Factor beta / metabolism
Tumor Necrosis Factor-alpha / metabolism
Chemical
Reg. No./Substance:
0/Cytokines; 0/Estrogens; 0/Hormones; 0/Peptides; 0/Transforming Growth Factor beta; 0/Tumor Necrosis Factor-alpha; 58-22-0/Testosterone; 9002-68-0/Follicle Stimulating Hormone

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