| Molecular mechanisms by which hormones and cytokines regulate cell junction dynamics in the testis. | |
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MedLine Citation:
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PMID: 19273571 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hormones and cytokines are known to regulate cellular functions in all tissues including testis. These two groups of biomolecules exert a broad spectrum of effects on various aspects of spermatogenesis. Among them, one of the regulatory effects on spermatogenesis is to modulate cell junction restructuring between Sertoli cells and between Sertoli and germ cells in the seminiferous epithelium. The restructuring of cell junctions is crucial to enable the migration of germ cells along the seminiferous epithelium from the basement membrane towards the tubular lumen, and at the same time for their attachment to Sertoli cells for support. This review will summarize the recent findings that focus on the role of hormones (FSH and testosterone) and cytokines (transforming growth factor-betas and tumor necrosis factor-alpha) on cell junction restructuring in the testis and the molecular mechanisms. |
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Authors:
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Wing-Yee Lui; Will M Lee |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2009-03-09 |
Journal Detail:
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Title: Journal of molecular endocrinology Volume: 43 ISSN: 1479-6813 ISO Abbreviation: J. Mol. Endocrinol. Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-07-20 Completed Date: 2009-09-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8902617 Medline TA: J Mol Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 43-51 Citation Subset: IM |
Affiliation:
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School of Biological Sciences, University of Hong Kong, Hong Kong, People's Republic of China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cytokines / metabolism* Estrogens / metabolism Follicle Stimulating Hormone / metabolism Hormones / metabolism* Intercellular Junctions / metabolism* Male Mice Peptides / metabolism Rats Spermatogenesis* Testis / metabolism* Testosterone / metabolism Transforming Growth Factor beta / metabolism Tumor Necrosis Factor-alpha / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Estrogens; 0/Hormones; 0/Peptides; 0/Transforming Growth Factor beta; 0/Tumor Necrosis Factor-alpha; 58-22-0/Testosterone; 9002-68-0/Follicle Stimulating Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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