| Molecular mechanisms of TNF-alpha-induced apoptosis in naïve and memory T cell subsets. | |
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MedLine Citation:
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PMID: 16697967 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aging in humans is associated with progressive decline in T cell function, hyperimmunoglobulinemia, increased prevalence of autoantibodies and decline in naïve CD8(+) T cells and accumulation of memory T cells, which appears to be oligoclonal and display feature of senescence, that is, decreased replication, short telomere length and resistance to apoptosis. Recently memory T cells have been further subdivided into central and effector memory T cells, based upon their migratory and homing properties. They are identified by a number of cell surface makers. In this brief review we will discuss molecular mechanisms of apoptosis in naïve and various types of memory T cells to possibly explain the changes observed in aging, which are very similar to certain autoimmune diseases. |
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Authors:
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Sudhir Gupta; Sastry Gollapudi |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2005-09-30 |
Journal Detail:
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Title: Autoimmunity reviews Volume: 5 ISSN: 1568-9972 ISO Abbreviation: Autoimmun Rev Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-05-15 Completed Date: 2006-08-10 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 101128967 Medline TA: Autoimmun Rev Country: Netherlands |
Other Details:
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Languages: eng Pagination: 264-8 Citation Subset: IM |
Affiliation:
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Division of Basic and Clinical Immunology, University of California, Irvine, 92697, USA. sgupta@ici.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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immunology* Antigens, CD95 / immunology Apoptosis / immunology* CD8-Positive T-Lymphocytes / immunology* Endoplasmic Reticulum / immunology Immunologic Memory / immunology* Mitochondria / immunology T-Lymphocyte Subsets / immunology* Tumor Necrosis Factor-alpha / immunology* |
| Grant Support | |
ID/Acronym/Agency:
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AG18313/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD95; 0/Tumor Necrosis Factor-alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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