Document Detail

Molecular mechanism and physiological functions of clathrin-mediated endocytosis.
MedLine Citation:
PMID:  21779028     Owner:  NLM     Status:  MEDLINE    
Clathrin-mediated endocytosis is the endocytic portal into cells through which cargo is packaged into vesicles with the aid of a clathrin coat. It is fundamental to neurotransmission, signal transduction and the regulation of many plasma membrane activities and is thus essential to higher eukaryotic life. Morphological stages of vesicle formation are mirrored by progression through various protein modules (complexes). The process involves the formation of a putative FCH domain only (FCHO) initiation complex, which matures through adaptor protein 2 (AP2)-dependent cargo selection, and subsequent coat building, dynamin-mediated scission and finally auxilin- and heat shock cognate 70 (HSC70)-dependent uncoating. Some modules can be used in other pathways, and additions or substitutions confer cell specificity and adaptability.
Harvey T McMahon; Emmanuel Boucrot
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2011-07-22
Journal Detail:
Title:  Nature reviews. Molecular cell biology     Volume:  12     ISSN:  1471-0080     ISO Abbreviation:  Nat. Rev. Mol. Cell Biol.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-22     Completed Date:  2011-09-20     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  100962782     Medline TA:  Nat Rev Mol Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  517-33     Citation Subset:  IM    
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MeSH Terms
Actins / physiology
Adaptor Protein Complex 2 / antagonists & inhibitors,  genetics,  physiology
Adaptor Proteins, Vesicular Transport / physiology
Clathrin / antagonists & inhibitors,  genetics,  physiology*
Clathrin-Coated Vesicles / physiology
Dynamins / physiology
Endocytosis / physiology*
Models, Biological
Neoplasms / etiology
RNA Interference
Signal Transduction
Synaptic Vesicles / physiology
Grant Support
MC_U105178795//Medical Research Council; //Medical Research Council
Reg. No./Substance:
0/Actins; 0/Adaptor Protein Complex 2; 0/Adaptor Proteins, Vesicular Transport; 0/Clathrin; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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