Document Detail


Molecular mechanism of juxtaglomerular cell hyperplasia: a unifying hypothesis.
MedLine Citation:
PMID:  20409848     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Renin is the first enzymatic step of the renin angiotensin cascade and plays an important role in cardiovascular homeostasis. Renin is mainly expressed in and released from specialized juxtaglomerular (JG) cells in kidney. JG cells develop hyperplasia in response to various chronic stimuli while maintaining the ability to express high levels of renin. However, the molecular and cellular mechanisms of JG cell hyperplasia are unknown. Based on the authors' previous observation that a nuclear hormone receptor, liver X receptor alpha, regulates renin expression as well as growth and differentiation genes such as c-myc, the authors propose the hypothesis that liver X receptor alpha can contribute to JG cell hyperplasia under conditions of chronic and intense induction of these genes. This hypothesis may provide a potential explanation for the observation that the JG cells can maintain a highly specialized renin-producing phenotype while undergoing hyperplasia.
Authors:
Kenichi Matsushita; Zhiping Zhang; Richard E Pratt; Victor J Dzau
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American Society of Hypertension : JASH     Volume:  1     ISSN:  1933-1711     ISO Abbreviation:  J Am Soc Hypertens     Publication Date:    2007 May-Jun
Date Detail:
Created Date:  2010-04-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101312518     Medline TA:  J Am Soc Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  164-8     Citation Subset:  -    
Affiliation:
Mandel Center for Hypertension Research, Duke University Medical Center, Durham, North Carolina, USA; Cardiology Division, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
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