Document Detail

Molecular mechanism of the interaction of subendothelial microfibrils with blood platelets.
MedLine Citation:
PMID:  1326097     Owner:  NLM     Status:  MEDLINE    
This short review summarizes the present state of our knowledge concerning the mechanisms of the interaction between subendothelial microfibrils and blood platelets. Microfibrils associated with elastin and with basement membranes have been shown to be able to promote platelet adhesion and subsequent activation and aggregation. A 128 kDa thrombospondin (TSP)-like glycoprotein of microfibrils (GP 128) is involved in their reactivity towards platelets, as established from specific inhibition by antibodies against GP 128 and against TSP of the microfibril-platelet interaction. This interaction only occurs in the presence of plasma von Willebrand factor (vWF). VWF effectively binds to microfibrils; this binding does not implicate GP 128, but a 97 kDa protein of microfibrils not yet characterized. In addition, from data based on inhibition of platelet adhesion and aggregation by monoclonal antibodies against platelet membrane glycoprotein Ib (GP Ib), it appears that GP Ib, a platelet membrane receptor for vWF, acts in the vWF dependent microfibril-platelet interaction as a receptor for VWF bound to protein 97 kDa in microfibrils. A tentative model is presented to illustrate the complex mechanism of the microfibril-platelet interactions: recognition of vWF bound to microfibrils by GP Ib would be the first step, which would then allow subsequent binding of GP 128 to its receptor on the platelet membrane.
Y J Legrand; F Fauvel-Lafève
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nouvelle revue française d'hématologie     Volume:  34     ISSN:  -     ISO Abbreviation:  Nouv Rev Fr Hematol     Publication Date:  1992  
Date Detail:
Created Date:  1992-10-15     Completed Date:  1992-10-15     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7909092     Medline TA:  Nouv Rev Fr Hematol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  17-25     Citation Subset:  IM    
INSERM U353, Institut d'Hématologie, Hôpital Saint-Louis, Paris, France.
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MeSH Terms
Antibodies, Monoclonal / immunology
Arteries / metabolism*
Basement Membrane / metabolism
Blood Platelets / metabolism*
Cross Reactions
Elastin / metabolism
Microfilaments / immunology,  metabolism*
Models, Biological
Platelet Adhesiveness
Platelet Membrane Glycoproteins / immunology,  metabolism*
Receptors, Cell Surface / metabolism*
von Willebrand Factor / metabolism
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Platelet Membrane Glycoproteins; 0/Receptors, Cell Surface; 0/Thrombospondins; 0/von Willebrand Factor; 0/von Willebrand factor receptor; 9007-58-3/Elastin

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