Document Detail


Molecular markers in pediatric neuro-oncology.
MedLine Citation:
PMID:  23095836     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pediatric molecular neuro-oncology is a fast developing field. A multitude of molecular profiling studies in recent years has unveiled a number of genetic abnormalities unique to pediatric brain tumors. It has now become clear that brain tumors that arise in children have distinct pathogenesis and biology, compared with their adult counterparts, even for those with indistinguishable histopathology. Some of the molecular features are so specific to a particular type of tumors, such as the presence of the KIAA1549-BRAF fusion gene for pilocytic astrocytomas or SMARCB1 mutations for atypical teratoid/rhabdoid tumors, that they could practically serve as a diagnostic marker on their own. Expression profiling has resolved the existence of 4 molecular subgroups in medulloblastomas, which positively translated into improved prognostication for the patients. The currently available molecular markers, however, do not cover all tumors even within a single tumor entity. The molecular pathogenesis of a large number of pediatric brain tumors is still unaccounted for, and the hierarchy of tumors is likely to be more complex and intricate than currently acknowledged. One of the main tasks of future molecular analyses in pediatric neuro-oncology, including the ongoing genome sequencing efforts, is to elucidate the biological basis of those orphan tumors. The ultimate goal of molecular diagnostics is to accurately predict the clinical and biological behavior of any tumor by means of their molecular characteristics, which is hoped to eventually pave the way for individualized treatment.
Authors:
Koichi Ichimura; Ryo Nishikawa; Masao Matsutani
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Neuro-oncology     Volume:  14 Suppl 4     ISSN:  1523-5866     ISO Abbreviation:  Neuro-oncology     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-10-25     Completed Date:  2013-06-19     Revised Date:  2013-09-03    
Medline Journal Info:
Nlm Unique ID:  100887420     Medline TA:  Neuro Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  iv90-9     Citation Subset:  IM    
Affiliation:
Division of Brain Tumor Translational Research, National Cancer Center Research Institute, Chuo-Ku, Tokyo, Japan. kichimur@ncc.go.jp
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MeSH Terms
Descriptor/Qualifier:
Brain Neoplasms / genetics*
Child
Humans
Medical Oncology / methods,  trends
Neurology / methods,  trends
Pathology, Molecular / methods*,  trends*
Pediatrics / methods,  trends
Tumor Markers, Biological / genetics*
Chemical
Reg. No./Substance:
0/Tumor Markers, Biological
Comments/Corrections

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