| Molecular magnetic resonance imaging of acute vascular cell adhesion molecule-1 expression in a mouse model of cerebral ischemia. | |
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MedLine Citation:
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PMID: 20087364 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The pathogenesis of stroke is multifactorial, and inflammation is thought to have a critical function in lesion progression at early time points. Detection of inflammatory processes associated with cerebral ischemia would be greatly beneficial in both designing individual therapeutic strategies and monitoring outcome. We have recently developed a new approach to imaging components of the inflammatory response, namely endovascular adhesion molecule expression on the brain endothelium. In this study, we show specific imaging of vascular cell adhesion molecule (VCAM)-1 expression in a mouse model of middle cerebral artery occlusion (MCAO), and a reduction in this inflammatory response, associated with improved behavioral outcome, as a result of preconditioning. The spatial extent of VCAM-1 expression is considerably greater than the detectable lesion using diffusion-weighted imaging (25% versus 3% total brain volume), which is generally taken to reflect the core of the lesion at early time points. Thus, VCAM-1 imaging seems to reveal both core and penumbral regions, and our data implicate VCAM-1 upregulation and associated inflammatory processes in the progression of penumbral tissue to infarction. Our findings indicate that such molecular magnetic resonance imaging (MRI) approaches could be important clinical tools for patient evaluation, acute monitoring of therapy, and design of specific treatment strategies. |
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Authors:
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Lisa C Hoyte; Keith J Brooks; Simon Nagel; Asim Akhtar; Ruoli Chen; Sylvie Mardiguian; Martina A McAteer; Daniel C Anthony; Robin P Choudhury; Alastair M Buchan; Nicola R Sibson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-01-20 |
Journal Detail:
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Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Volume: 30 ISSN: 1559-7016 ISO Abbreviation: J. Cereb. Blood Flow Metab. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-01 Completed Date: 2010-06-17 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 8112566 Medline TA: J Cereb Blood Flow Metab Country: United States |
Other Details:
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Languages: eng Pagination: 1178-87 Citation Subset: IM |
Affiliation:
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Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Disease Models, Animal Endothelium, Vascular / metabolism*, radiography Gene Expression Regulation* Humans Infarction, Middle Cerebral Artery / metabolism*, radiography Inflammation / metabolism, radiography Ischemic Preconditioning / methods Magnetic Resonance Imaging* Mice Monitoring, Physiologic / methods Vascular Cell Adhesion Molecule-1 / biosynthesis* |
| Grant Support | |
ID/Acronym/Agency:
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//Canadian Institutes of Health Research; //Cancer Research UK; //Medical Research Council; //Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Vascular Cell Adhesion Molecule-1 |
| Comments/Corrections | |
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