Document Detail


Molecular machines governing exocytosis of synaptic vesicles.
MedLine Citation:
PMID:  23060190     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Calcium-dependent exocytosis of synaptic vesicles mediates the release of neurotransmitters. Important proteins in this process have been identified such as the SNAREs, synaptotagmins, complexins, Munc18 and Munc13. Structural and functional studies have yielded a wealth of information about the physiological role of these proteins. However, it has been surprisingly difficult to arrive at a unified picture of the molecular sequence of events from vesicle docking to calcium-triggered membrane fusion. Using mainly a biochemical and biophysical perspective, we briefly survey the molecular mechanisms in an attempt to functionally integrate the key proteins into the emerging picture of the neuronal fusion machine.
Authors:
Reinhard Jahn; Dirk Fasshauer
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nature     Volume:  490     ISSN:  1476-4687     ISO Abbreviation:  Nature     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  England    
Other Details:
Languages:  eng     Pagination:  201-7     Citation Subset:  IM    
Affiliation:
Department of Neurobiology, Max-Planck-Institute for Biophysical Chemistry, 37077 Göttingen, Germany. rjahn@gwdg.de
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MeSH Terms
Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
3P01GM072694-05S1/GM/NIGMS NIH HHS

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