| Molecular machinery of signal transduction and cell cycle regulation in Plasmodium. | |
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MedLine Citation:
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PMID: 19393157 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The regulation of the Plasmodium cell cycle is not understood. Although the Plasmodium falciparum genome is completely sequenced, about 60% of the predicted proteins share little or no sequence similarity with other eukaryotes. This feature impairs the identification of important proteins participating in the regulation of the cell cycle. There are several open questions that concern cell cycle progression in malaria parasites, including the mechanism by which multiple nuclear divisions is controlled and how the cell cycle is managed in all phases of their complex life cycle. Cell cycle synchrony of the parasite population within the host, as well as the circadian rhythm of proliferation, are striking features of some Plasmodium species, the molecular basis of which remains to be elucidated. In this review we discuss the role of indole-related molecules as signals that modulate the cell cycle in Plasmodium and other eukaryotes, and we also consider the possible role of kinases in the signal transduction and in the responses it triggers. |
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Authors:
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Fernanda C Koyama; Debopam Chakrabarti; Célia R S Garcia |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2009-01-21 |
Journal Detail:
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Title: Molecular and biochemical parasitology Volume: 165 ISSN: 0166-6851 ISO Abbreviation: Mol. Biochem. Parasitol. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-04-27 Completed Date: 2009-05-12 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 8006324 Medline TA: Mol Biochem Parasitol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1-7 Citation Subset: IM |
Affiliation:
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Departamento de Fisiologia, Instituto de Biociências, Universidade de São Paulo, São Paulo, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle / physiology* Plasmodium / enzymology, physiology* Protein Kinases / metabolism Signal Transduction / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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AI73795/AI/NIAID NIH HHS; R01 AI073795-01A2/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 2.7.-/Protein Kinases |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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