| Molecular links between mammary gland development and breast cancer. | |
| | |
MedLine Citation:
|
PMID: 17955178 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
During its lifetime, the mammary gland undergoes many phases of development and differentiation. Much of this occurs during puberty, when the ductal epithelium expands by branching morphogenesis, invading the surrounding fat pad to form an organised mammary tree. Throughout its existence, the epithelium will go through several cycles of proliferation and cell death during pregnancy, lactation and involution. Many of the signalling mechanisms which control the initial invasion of the fat pad by the epithelium, and regulate its continuing plasticity, can be harnessed or corrupted by tumour cells in order to support their aberrant growth and progression towards invasion. This is true not just for the epithelial cells themselves but also for cells in the surrounding microenvironment, including fibroblasts, macrophages and adipocytes. This review examines the complex web of signalling and adhesion interactions controlling branching morphogenesis, and how their alteration can promote malignancy. Current in vivo and in vitro mammary gland models are also discussed. (Part of a Multi-author Review). |
| | |
Authors:
|
F Lanigan; D O'Connor; F Martin; W M Gallagher |
Related Documents
:
|
12166628 - Estradiol and progesterone regulate oxytocin receptor binding and expression in human b... 20036708 - The müllerian hoxa10 gene promotes growth of ovarian surface epithelial cells by stimu... 304048 - Growth requirements of human mammary epithelial cells in culture. 10887478 - Role of mesenchymal-epithelial interactions in mammary gland development. 18651278 - A new cell-based fe model for the mechanics of embryonic epithelia. 20166988 - Signalling pathways activated by ultraviolet radiation: role in ocular and cutaneous he... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Cellular and molecular life sciences : CMLS Volume: 64 ISSN: 1420-682X ISO Abbreviation: Cell. Mol. Life Sci. Publication Date: 2007 Dec |
Date Detail:
|
Created Date: 2008-01-21 Completed Date: 2008-02-29 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9705402 Medline TA: Cell Mol Life Sci Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 3159-84 Citation Subset: IM |
Affiliation:
|
UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Breast Neoplasms / genetics*, metabolism Cell Adhesion / physiology Epidermal Growth Factor / genetics, physiology Humans Mammary Glands, Animal / growth & development, metabolism Mammary Glands, Human / growth & development*, metabolism Matrix Metalloproteinases / genetics, metabolism, physiology Models, Biological Neoplasm Invasiveness Oncogene Proteins v-erbB / genetics, physiology Stem Cells / physiology Transcription Factors / genetics, physiology Transforming Growth Factor beta / genetics, physiology |
| Chemical | |
Reg. No./Substance:
|
0/Oncogene Proteins v-erbB; 0/Transcription Factors; 0/Transforming Growth Factor beta; 62229-50-9/Epidermal Growth Factor; EC 3.4.24.-/Matrix Metalloproteinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Mammary stem cells and breast cancer.
Next Document: Histone chaperones: 30 years from isolation to elucidation of the mechanisms of nucleosome assembly ...