Document Detail


Molecular links between mammary gland development and breast cancer.
MedLine Citation:
PMID:  17955178     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During its lifetime, the mammary gland undergoes many phases of development and differentiation. Much of this occurs during puberty, when the ductal epithelium expands by branching morphogenesis, invading the surrounding fat pad to form an organised mammary tree. Throughout its existence, the epithelium will go through several cycles of proliferation and cell death during pregnancy, lactation and involution. Many of the signalling mechanisms which control the initial invasion of the fat pad by the epithelium, and regulate its continuing plasticity, can be harnessed or corrupted by tumour cells in order to support their aberrant growth and progression towards invasion. This is true not just for the epithelial cells themselves but also for cells in the surrounding microenvironment, including fibroblasts, macrophages and adipocytes. This review examines the complex web of signalling and adhesion interactions controlling branching morphogenesis, and how their alteration can promote malignancy. Current in vivo and in vitro mammary gland models are also discussed. (Part of a Multi-author Review).
Authors:
F Lanigan; D O'Connor; F Martin; W M Gallagher
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Cellular and molecular life sciences : CMLS     Volume:  64     ISSN:  1420-682X     ISO Abbreviation:  Cell. Mol. Life Sci.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2008-01-21     Completed Date:  2008-02-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9705402     Medline TA:  Cell Mol Life Sci     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  3159-84     Citation Subset:  IM    
Affiliation:
UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland.
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MeSH Terms
Descriptor/Qualifier:
Animals
Breast Neoplasms / genetics*,  metabolism
Cell Adhesion / physiology
Epidermal Growth Factor / genetics,  physiology
Humans
Mammary Glands, Animal / growth & development,  metabolism
Mammary Glands, Human / growth & development*,  metabolism
Matrix Metalloproteinases / genetics,  metabolism,  physiology
Models, Biological
Neoplasm Invasiveness
Oncogene Proteins v-erbB / genetics,  physiology
Stem Cells / physiology
Transcription Factors / genetics,  physiology
Transforming Growth Factor beta / genetics,  physiology
Chemical
Reg. No./Substance:
0/Oncogene Proteins v-erbB; 0/Transcription Factors; 0/Transforming Growth Factor beta; 62229-50-9/Epidermal Growth Factor; EC 3.4.24.-/Matrix Metalloproteinases

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