Document Detail


Molecular interpretation of expanded RED products in bipolar disorder by CAG/CTG repeats located at chromosomes 17q and 18q.
MedLine Citation:
PMID:  10527808     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previously we provided evidence that the anticipation observed in bipolar (BP) disorder may be explained by expanded CAG/CTG triplet repeats. Data were generated with the repeat expansion detection (RED) method in a BP case-control sample showing a significant association of BP disorder with expanded CAG/CTG repeats (RED products of 120 bp). In this study we demonstrated that 86% of the RED expansions could be accounted for by the ERDA1 and CTG18.1 CAG/CTG repeats located respectively on chromosomes 17 and 18. Further, significantly different allele distributions were observed for ERDA1, with a larger proportion of BP patients (34.7%) carrying one or two expanded ERDA1 alleles (CAG/CTG repeats >40) than controls (19.2%) (P = 0.032). Also, a negative correlation was observed for ERDA1 between CAG/CTG length and age at onset in affected offspring of eight BP families. Although interesting, these data should be interpreted with caution since the ERDA1 association did not remain significant after correcting for multiple testing. Also, no linkage was observed between BP disorder and expanded ERDA1 alleles in the families.
Authors:
G R Verheyen; J Del-Favero; J Mendlewicz; K Lindblad; K Van Zand; M Aalbregtse; M Schalling; D Souery; C Van Broeckhoven
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurobiology of disease     Volume:  6     ISSN:  0969-9961     ISO Abbreviation:  Neurobiol. Dis.     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-12-06     Completed Date:  1999-12-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9500169     Medline TA:  Neurobiol Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  424-32     Citation Subset:  IM    
Copyright Information:
Copyright 1999 Academic Press.
Affiliation:
Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Universiteitsplein 1, Antwerp, B-2610, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Base Sequence
Bipolar Disorder / genetics*
Chromosome Mapping
Chromosomes, Human, Pair 17*
Chromosomes, Human, Pair 18*
Family
Female
Humans
Male
Pedigree
Polymerase Chain Reaction
Reference Values
Trinucleotide Repeats*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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