Document Detail

Molecular interactions continuously define the organizer during the cell movements of gastrulation.
MedLine Citation:
PMID:  10490096     Owner:  NLM     Status:  MEDLINE    
The organizer is a unique region in the gastrulating embryo that induces and patterns the body axis. It arises before gastrulation under the influence of the Nieuwkoop center. We show that during gastrulation, cell movements bring cells into and out of the chick organizer, Hensen's node. During these movements, cells acquire and lose organizer properties according to their position. A "node inducing center," which emits Vg1 and Wnt8C, is located in the middle of the primitive streak. Its activity is inhibited by ADMP produced by the node and by BMPs at the periphery. These interactions define the organizer as a position in the embryo, whose cellular makeup is constantly changing, and explain the phenomenon of organizer regeneration.
K Joubin; C D Stern
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cell     Volume:  98     ISSN:  0092-8674     ISO Abbreviation:  Cell     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-10-01     Completed Date:  1999-10-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  559-71     Citation Subset:  IM    
Department of Genetics and Development, and Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA.
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MeSH Terms
Amino Acid Sequence
Bone Morphogenetic Proteins / metabolism
COS Cells
Cell Lineage
Cell Movement
Chick Embryo
Endoderm / metabolism
Feedback / physiology
Gastrula / physiology*
Gene Expression Regulation, Developmental*
Glycoproteins / metabolism,  physiology
Intercellular Signaling Peptides and Proteins*
Models, Biological
Molecular Sequence Data
Proto-Oncogene Proteins / physiology
Sequence Homology, Amino Acid
Time Factors
Transforming Growth Factor beta
Wnt Proteins
Zebrafish Proteins*
Grant Support
Reg. No./Substance:
0/Bone Morphogenetic Proteins; 0/Glycoproteins; 0/Intercellular Signaling Peptides and Proteins; 0/Proto-Oncogene Proteins; 0/Transforming Growth Factor beta; 0/Wnt Proteins; 0/Zebrafish Proteins; 93586-27-7/chordin

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