| Molecular insights into dietary induced colic in the horse. | |
| | |
MedLine Citation:
|
PMID: 18487108 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Equine colic, a disorder manifested in abdominal pain, is the most frequent cause of emergency treatment and death in horses. Colic often requires intestinal surgery, subsequent hospitalisation and post operative care, with a strong risk of complications arising from surgery. Therefore strategies that explore approaches for preventing the condition are essential. To this end, a better understanding of the factors and mechanisms that lead to the development of colic and related intestinal diseases in the horse allows the design of preventive procedures. Colic is a multifactorial disorder that appears to be induced by environmental factors and possibly a genetic predisposition. One factor that seems to influence the risk of developing colic is the excessive consumption of diets containing high levels of carbohydrates. Therefore, major efforts have been made by various laboratories and institutions across the world to study the type and digestibility of various feed in order to formulate accurate and safe feed components and proportions. However, relatively little work has been carried out to characterise, in detail, the carbohydrate digestive and absorptive capacity and mechanisms underlying the potential adaptive response of equine gut epithelium to a changing diet. This review focuses on advances made towards understanding the molecular and cellular mechanisms involved in digestion and absorption of dietary carbohydrates in the equine gastrointestinal tract and the implication of these processes for the whole body physiology. It addresses the underlying mechanisms that may govern the adaptive response of equine small intestine to increased dietary hydrolysable carbohydrates. Furthermore, it describes changes that occur in the equine large intestinal microbiology and host tissue biology brought about by alterations in diet and in colic. It is hoped that a better understanding of the molecular and cellular processes that play important roles in the physiology and pathology of the equine gastrointestinal tract will assist the development of effective strategies to prevent equine colic. |
| | |
Authors:
|
S P Shirazi-Beechey |
Related Documents
:
|
8889958 - Reversal of altered intestinal mucosal immunity in rats fed elemental diet by supplemen... 18704608 - Effect of intestinal pacing on small bowel transit and nutrient absorption in healthy v... 8998878 - The effect of hallux sesamoid excision on the flexor hallucis longus moment arm. 196358 - Transmissible gastro-enteritis of swine in the netherlands the application of the direc... 22579608 - The natural outcome of melamine-induced bladder stones with bladder epithelial hyperpla... 10710268 - Effect of resistance exercise (body building) training on serum leptin levels in young ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Equine veterinary journal Volume: 40 ISSN: 0425-1644 ISO Abbreviation: Equine Vet. J. Publication Date: 2008 Jun |
Date Detail:
|
Created Date: 2008-08-01 Completed Date: 2008-10-03 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 0173320 Medline TA: Equine Vet J Country: England |
Other Details:
|
Languages: eng Pagination: 414-21 Citation Subset: IM |
Affiliation:
|
Epithelial Function and Development Group, Department of Veterinary Preclinical Sciences, University of Liverpool, Liverpool, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Abdominal Pain
/
etiology,
veterinary Animal Feed / adverse effects* Animal Nutritional Physiological Phenomena Animals Colic / etiology, metabolism, veterinary* Dietary Carbohydrates / administration & dosage, adverse effects, pharmacokinetics* Digestion Gastrointestinal Transit Horse Diseases / etiology, metabolism* Horses / metabolism, physiology* Intestinal Absorption |
| Chemical | |
Reg. No./Substance:
|
0/Dietary Carbohydrates |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Equine gastrointestinal motility research: where we are and where we need to go.
Next Document: Epiphyseal cartilage canal blood supply to the distal femur of foals.