| Molecular imaging with dynamic contrast-enhanced computed tomography. | |
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MedLine Citation:
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PMID: 20541654 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dynamic contrast-enhanced computed tomography (DCE-CT) is a quantitative technique that employs rapid sequences of CT images after bolus administration of intravenous contrast material to measure a range of physiological processes related to the microvasculature of tissues. By combining knowledge of the molecular processes underlying changes in vascular physiology with an understanding of the relationship between vascular physiology and CT contrast enhancement, DCE-CT can be redefined as a molecular imaging technique. Some DCE-CT derived parameters reflect tissue hypoxia and can, therefore, provide information about the cellular microenvironment. DCE-CT can also depict physiological processes, such as vasodilatation, that represent the physiological consequences of molecular responses to tissue hypoxia. To date the main applications have been in stroke and oncology. Unlike some other molecular imaging approaches, DCE-CT benefits from wide availability and ease of application along with the use of contrast materials and software packages that have achieved full regulatory approval. Hence, DCE-CT represents a molecular imaging technique that is applicable in clinical practice today. |
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Authors:
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K A Miles |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical radiology Volume: 65 ISSN: 1365-229X ISO Abbreviation: Clin Radiol Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-14 Completed Date: 2010-11-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1306016 Medline TA: Clin Radiol Country: England |
Other Details:
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Languages: eng Pagination: 549-56 Citation Subset: IM |
Copyright Information:
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Copyright 2010 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Clinical Imaging Sciences Centre, Brighton & Sussex Medical School, University of Sussex, Falmer, Brighton, UK. k.a.miles@bsms.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Vessels Contrast Media / administration & dosage, diagnostic use* Humans Molecular Imaging / methods* Neoplasms / pathology, radiography* Neovascularization, Pathologic / pathology, radiography* Stroke / physiopathology, radiography* Tomography, X-Ray Computed / methods |
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Reg. No./Substance:
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0/Contrast Media |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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