| Molecular imaging of human embryonic stem cells: keeping an eye on differentiation, tumorigenicity and immunogenicity. | |
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MedLine Citation:
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PMID: 17172859 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Human embryonic stem cells (hESCs) are capable of differentiation into every cell type of the human being. They are under extensive investigation for their regenerative potential in a variety of debilitating diseases. However, the field of hESC research is still in its infancy, as there are several critical issues that need to be resolved before clinical translation. Two major concerns are the ability of undifferentiated hESCs to form teratomas and the possibility of a provoked immune reaction after transplantation of hESCs into a new host. Therefore, it is imperative to develop noninvasive imaging modalities that allow for longitudinal, repetitive, and quantitative assessment of transplanted cell survival, proliferation, and migration in vivo. Reporter gene-based molecular imaging offers these characteristics and has great potential in the field of stem cell therapy. Moreover, it has recently been shown that reporter gene imaging can be combined with therapeutic strategies. Here, we provide an outline of the current status of hESC research and discuss the concerns of tumorigenicity and immunogenicity. Furthermore, we describe how molecular imaging can be utilized to follow and resolve these issues. |
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Authors:
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Koen E A van der Bogt; Rutger-Jan Swijnenburg; Feng Cao; Joseph C Wu |
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Publication Detail:
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Type: Journal Article Date: 2006-12-01 |
Journal Detail:
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Title: Cell cycle (Georgetown, Tex.) Volume: 5 ISSN: 1551-4005 ISO Abbreviation: Cell Cycle Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-12-25 Completed Date: 2007-01-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101137841 Medline TA: Cell Cycle Country: United States |
Other Details:
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Languages: eng Pagination: 2748-52 Citation Subset: IM |
Affiliation:
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Department of Medicine, Division of Cardiology, Stanford University School of Medicine, Stanford, California, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Differentiation* Cell Lineage Ectoderm / cytology Embryonic Stem Cells / cytology*, immunology* Endoderm / cytology Humans Luminescent Proteins / metabolism Mesoderm / cytology Stem Cell Transplantation Teratoma / pathology* |
| Chemical | |
Reg. No./Substance:
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0/Luminescent Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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