Document Detail

Molecular imaging of epidermal growth factor-receptor and survivin in vivo in porcine esophageal and gastric mucosae using probe-based confocal laser-induced endomicroscopy: proof of concept.
MedLine Citation:
PMID:  22791645     Owner:  NLM     Status:  MEDLINE    
RESULTS: CLE enabled visualization of EGF-R and survivin in esophageal and gastric mucosa and this was confirmed by histology. In the esophagus both EGF-R and survivin were localized predominantly to the keratinocyte progenitor cells. In the stomach, EGF-R was localized to progenitor zone cells and some epithelial cells. Localization of survivin was similar, but involved more surface epithelial cells. This study demonstrated feasibility of using CLE and topical administration of FITC labeled antibodies for in vivo localization of EGF-R and survivin in esophageal and gastric mucosa.
Y Nakai; S Shinoura; A Ahluwalia; A S Tarnawski; K J Chang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society     Volume:  63     ISSN:  1899-1505     ISO Abbreviation:  J. Physiol. Pharmacol.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-07-13     Completed Date:  2013-02-13     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  9114501     Medline TA:  J Physiol Pharmacol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  303-7     Citation Subset:  IM    
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MeSH Terms
Esophagus / metabolism*
Gastric Mucosa / metabolism*
Keratinocytes / metabolism
Microscopy, Confocal / methods*
Molecular Imaging / methods*
Pilot Projects
Receptor, Epidermal Growth Factor / metabolism*
Stem Cells / metabolism
Stomach / metabolism
Reg. No./Substance:
EC, Epidermal Growth Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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