Document Detail


Molecular imaging of angiogenesis with SPECT.
MedLine Citation:
PMID:  20617435     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Single-photon emission computed tomography (SPECT) and position emission tomography (PET) are the two main imaging modalities in nuclear medicine. SPECT imaging is more widely available than PET imaging and the radionuclides used for SPECT are easier to prepare and usually have a longer half-life than those used for PET. In addition, SPECT is a less expensive technique than PET. Commonly used gamma emitters are: (99m)Tc (E(max) 141 keV, T (1/2) 6.02 h), (123)I (E(max) 529 keV, T (1/2) 13.0 h) and (111)In (E(max) 245 keV, T (1/2) 67.2 h). Compared to clinical SPECT, PET has a higher spatial resolution and the possibility to more accurately estimate the in vivo concentration of a tracer. In preclinical imaging, the situation is quite different. The resolution of microSPECT cameras (<0.5 mm) is higher than that of microPET cameras (>1.5 mm). In this report, studies on new radiolabelled tracers for SPECT imaging of angiogenesis in tumours are reviewed.
Authors:
Ingrid Dijkgraaf; Otto C Boerman
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  European journal of nuclear medicine and molecular imaging     Volume:  37 Suppl 1     ISSN:  1619-7089     ISO Abbreviation:  Eur. J. Nucl. Med. Mol. Imaging     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-04     Completed Date:  2010-12-29     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101140988     Medline TA:  Eur J Nucl Med Mol Imaging     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  S104-13     Citation Subset:  IM    
Affiliation:
Department of Nuclear Medicine, Radboud University Nijmegen Medical Center, The Netherlands. I.Dijkgraaf@nucmed.umcn.nl
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MeSH Terms
Descriptor/Qualifier:
Animals
Extracellular Matrix Proteins / metabolism
Humans
Integrin alphaVbeta3 / metabolism
Neovascularization, Pathologic / metabolism,  radionuclide imaging*
Prostate-Specific Antigen / metabolism
Receptors, Vascular Endothelial Growth Factor / metabolism
Tomography, Emission-Computed, Single-Photon / methods*
Chemical
Reg. No./Substance:
0/Extracellular Matrix Proteins; 0/Integrin alphaVbeta3; EC 2.7.10.1/Receptors, Vascular Endothelial Growth Factor; EC 3.4.21.77/Prostate-Specific Antigen
Comments/Corrections

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