| Molecular histology on the diagnostic cutting edge between malignant melanomas and cutaneous melanocytomas (Review). | |
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MedLine Citation:
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PMID: 19885575 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In recent years, the screening accuracy of clinical dermoscopy has increased in the early detection of evolving atypical melanocytic neoplasms. However, the most dramatic cases of human malignant melanomas (MM), i.e. the fast-growing neoplasms, usually escape the classical clinical criteria of MM. As a result, a number of puzzling cases exhibit uncertain clues for MM. Thus, the risk of microscopic misdiagnosis is likely on the rise if the histological criteria are not fine-tuned. This review summarizes a conceptual classification of atypical melanocytic neoplasms grouped under the heading of melanocytomas. Some immunohistochemical markers are tentatively used as discriminators between fast-growing MM and melanocytomas. However, some differences seem to be more statistically significant than clinically useful due to extensive overlap in immunoreactivity from any case to case. A multipronged immunohistological screening is therefore welcome. |
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Authors:
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Pascale Quatresooz; Claudine Pierard-Franchimont; Gerald E Pierard; |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Oncology reports Volume: 22 ISSN: 1791-2431 ISO Abbreviation: Oncol. Rep. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-03 Completed Date: 2010-02-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9422756 Medline TA: Oncol Rep Country: Greece |
Other Details:
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Languages: eng Pagination: 1263-7 Citation Subset: IM |
Affiliation:
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Department of Dermatopathology, University Hospital of Li?ge, Li?ge, Belgium. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis Cell Proliferation Dermatology / methods Humans Immunohistochemistry / methods Medical Oncology / methods Melanoma / diagnosis*, pathology Neoplasm Metastasis Nevus / pathology Phenotype Skin Neoplasms / diagnosis*, pathology |
| Investigator | |
Investigator/Affiliation:
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J E Arrese / ; G Blaise / ; R Bourguignon / ; C Braham / ; M Broux / ; N Claessens / ; F Cornil / ; M Dameaux / ; J M Darcis / ; J Dehavay / ; P Delvoye / ; C Devillers / ; A L Fraiture / ; C Franchimont / ; I Fumal / ; V Goffin / ; F Henry / ; J F Hermanns / ; T L? / ; M Lesuisse / ; C Letawe / ; B Letot / ; O Martalo / ; F Mauhin / ; A Nikkels / ; P Paquet / ; G E Pi?rard / ; P Quatresooz / ; G Szepetiuk / ; N Tassoudji / ; L Thirion / ; I Uhoda / ; G Vandenbossche / ; V Willemaers / |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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