Document Detail


Molecular histology on the diagnostic cutting edge between malignant melanomas and cutaneous melanocytomas (Review).
MedLine Citation:
PMID:  19885575     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In recent years, the screening accuracy of clinical dermoscopy has increased in the early detection of evolving atypical melanocytic neoplasms. However, the most dramatic cases of human malignant melanomas (MM), i.e. the fast-growing neoplasms, usually escape the classical clinical criteria of MM. As a result, a number of puzzling cases exhibit uncertain clues for MM. Thus, the risk of microscopic misdiagnosis is likely on the rise if the histological criteria are not fine-tuned. This review summarizes a conceptual classification of atypical melanocytic neoplasms grouped under the heading of melanocytomas. Some immunohistochemical markers are tentatively used as discriminators between fast-growing MM and melanocytomas. However, some differences seem to be more statistically significant than clinically useful due to extensive overlap in immunoreactivity from any case to case. A multipronged immunohistological screening is therefore welcome.
Authors:
Pascale Quatresooz; Claudine Pierard-Franchimont; Gerald E Pierard;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Oncology reports     Volume:  22     ISSN:  1791-2431     ISO Abbreviation:  Oncol. Rep.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-03     Completed Date:  2010-02-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9422756     Medline TA:  Oncol Rep     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  1263-7     Citation Subset:  IM    
Affiliation:
Department of Dermatopathology, University Hospital of Li?ge, Li?ge, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Apoptosis
Cell Proliferation
Dermatology / methods
Humans
Immunohistochemistry / methods
Medical Oncology / methods
Melanoma / diagnosis*,  pathology
Neoplasm Metastasis
Nevus / pathology
Phenotype
Skin Neoplasms / diagnosis*,  pathology
Investigator
Investigator/Affiliation:
J E Arrese / ; G Blaise / ; R Bourguignon / ; C Braham / ; M Broux / ; N Claessens / ; F Cornil / ; M Dameaux / ; J M Darcis / ; J Dehavay / ; P Delvoye / ; C Devillers / ; A L Fraiture / ; C Franchimont / ; I Fumal / ; V Goffin / ; F Henry / ; J F Hermanns / ; T L? / ; M Lesuisse / ; C Letawe / ; B Letot / ; O Martalo / ; F Mauhin / ; A Nikkels / ; P Paquet / ; G E Pi?rard / ; P Quatresooz / ; G Szepetiuk / ; N Tassoudji / ; L Thirion / ; I Uhoda / ; G Vandenbossche / ; V Willemaers /

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