Document Detail


Molecular heterogeneity and centrosome-associated genes in multiple myeloma.
MedLine Citation:
PMID:  23323949     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
ABSTRACT In multiple myeloma (MM), biologic complexity originates from complex oncogenic processes involving somatic acquisition of myriad mutations coupled with genetic variability within the host. This pathogenically determined molecular heterogeneity predetermines clinical intricacy. In this study, we performed gene expression profiling (GEP) focusing on centrosome-related genes to determine the molecular heterogeneity for centrosome-associated genes in MM patients. We identified the gene pattern with impact on myeloma pathogenesis. According to expression tendency three subgroups of patients were established. Revealed molecular signature is related to overall survival as well as to clinical parameters and the International Staging System (ISS). Associations with integral clinical parameters allow us to proclaim the impact of the revealed functional gene set in MM genesis. We believe that future investigation of this molecular heterogeneity will help to refine the broad prognoses offered by present-day established systems and even substratify them.
Authors:
Fedor Kryukov; Pavel Nemec; Elena Dementyeva; Lenka Kubiczkova; Ivana Ihnatova; Eva Budinska; Jiri Jarkovsky; Sabina Sevcikova; Petr Kuglik; Roman Hajek
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-17
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  -     ISSN:  1029-2403     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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