| Molecular gradient along the axon pathway is not required for directional axon growth. | |
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MedLine Citation:
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PMID: 9670998 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We show that axon guidance of embryonic hippocampal neurons is promoted by pathways of a decapeptide (RDIAEIIKDI) derived from a neurite outgrowth domain of the gamma1 chain of laminin-1. This guidance is directly dependent on: (1) a concentration difference of the decapeptide between the peptide pathway and its surrounding areas, and (2) the optimal surface geometry of the decapeptide pathway. These results indicate that axon guidance of central neurons may proceed along a preferred substratum pathway without a concentration gradient of the guiding molecule along this pathway, or without a repulsive molecule next to the axon pathway. |
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Authors:
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M Matsuzawa; S Tokumitsu; W Knoll; P Liesi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of neuroscience research Volume: 53 ISSN: 0360-4012 ISO Abbreviation: J. Neurosci. Res. Publication Date: 1998 Jul |
Date Detail:
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Created Date: 1998-09-24 Completed Date: 1998-09-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600111 Medline TA: J Neurosci Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 114-24 Citation Subset: IM |
Affiliation:
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Lab for Exotic Nanomaterials, Frontier Research Program, Wako, Saitama, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Axons / metabolism* Cell Differentiation / drug effects Cells, Cultured Cerebellum / cytology Hippocampus / cytology Immunohistochemistry Isomerism Laminin / chemistry, pharmacology* Neural Pathways / cytology, growth & development*, metabolism* Neuropeptides / pharmacology* Rats Surface Properties Videotape Recording |
| Chemical | |
Reg. No./Substance:
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0/Laminin; 0/Neuropeptides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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