Document Detail

Molecular genetics of sudden cardiac death.
MedLine Citation:
PMID:  18992999     Owner:  NLM     Status:  MEDLINE    
Sudden cardiac death (SCD) is one of the most common causes of death. An important number of sudden deaths, especially in the young, are due to genetic heart disorders, both with structural and arrhythmogenic abnormalities. In recent years, significant advances have been made in understanding the genetic basis of SCD. Identification of the genetic causes of sudden death is important because close relatives are also at potential risk of having a fatal cardiac condition. A comprehensive post-mortem investigation is vital to determine the cause and manner of death and provides the opportunity to assess the potential risk to the family after appropriate genetic counselling. In this paper, we present an update of the different genetic causes of sudden death, emphasizing their importance for the forensic pathologist due to his relevant role in the diagnosis and prevention of SCD.
María Sol Rodríguez-Calvo; María Brion; Catarina Allegue; Luis Concheiro; Angel Carracedo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-11-07
Journal Detail:
Title:  Forensic science international     Volume:  182     ISSN:  1872-6283     ISO Abbreviation:  Forensic Sci. Int.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-28     Completed Date:  2009-04-10     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7902034     Medline TA:  Forensic Sci Int     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  1-12     Citation Subset:  IM    
Institute of Legal Medicine, University of Santiago de Compostela, Spain.
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MeSH Terms
Catecholamines / metabolism
Channelopathies / complications
Death, Sudden, Cardiac / etiology*
Forensic Pathology
Genetic Predisposition to Disease
Genetic Testing
Heart Diseases / diagnosis,  genetics*,  metabolism
Physician's Role
Reg. No./Substance:

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