Document Detail

Molecular genetics and subjective well-being.
MedLine Citation:
PMID:  23708117     Owner:  NLM     Status:  MEDLINE    
Subjective well-being (SWB) is a major topic of research across the social sciences. Twin and family studies have found that genetic factors may account for as much as 30-40% of the variance in SWB. Here, we study genetic contributions to SWB in a pooled sample of ≈ 11,500 unrelated, comprehensively-genotyped Swedish and Dutch individuals. We apply a recently developed method to estimate "common narrow heritability": the fraction of variance in SWB that can be explained by the cumulative additive effects of genetic polymorphisms that are common in the population. Our estimates are 5-10% for single-question survey measures of SWB, and 12-18% after correction for measurement error in the SWB measures. Our results suggest guarded optimism about the prospects of using genetic data in SWB research because, although the common narrow heritability is not large, the polymorphisms that contribute to it could feasibly be discovered with a sufficiently large sample of individuals.
Cornelius A Rietveld; David Cesarini; Daniel J Benjamin; Philipp D Koellinger; Jan-Emmanuel De Neve; Henning Tiemeier; Magnus Johannesson; Patrik K E Magnusson; Nancy L Pedersen; Robert F Krueger; Meike Bartels
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Twin Study     Date:  2013-05-24
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  110     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-06-12     Completed Date:  2013-08-23     Revised Date:  2014-05-01    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  9692-7     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Gene Frequency
Middle Aged
Personal Satisfaction*
Polymorphism, Single Nucleotide
Registries / statistics & numerical data
Twins, Dizygotic / genetics*
Twins, Monozygotic / genetics*
Grant Support
DK U01-066134/DK/NIDDK NIH HHS; P01-AG005842/AG/NIA NIH HHS; P01-AG005842-20S2/AG/NIA NIH HHS; P30-AG012810/AG/NIA NIH HHS; R01 AG040640/AG/NIA NIH HHS; R01-AG040640/AG/NIA NIH HHS; R01-AG040787/AG/NIA NIH HHS; T32-AG000186-23/AG/NIA NIH HHS; T32-AG00186/AG/NIA NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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