Document Detail


Molecular genetics of human leukemia.
MedLine Citation:
PMID:  9777887     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human leukemias are clonal hemopathies generally characterized by acquired somatic mutations, including translocations, deletions, and insertions. Ten years ago, the first leukemia-related chromosomal translocation, the Philadelphia chromosome, was cloned and fully characterized at the molecular level. Since then, a plethora of chromosomal translocations and mutations has been associated with leukemogenesis. Analysis and comparison of this bewildering array of genetic changes have helped identify shared paradigms and themes in the mechanisms of transformation of hematopoietic cells. This information will guide the development of improved therapies that take into account the cytogenetic and molecular characteristics of human leukemias. This review summarizes the current knowledge of the nature of the genetic changes associated with leukemogenesis and discusses their consequences at the molecular and cellular levels.
Authors:
D G Gilliland
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Leukemia     Volume:  12 Suppl 1     ISSN:  0887-6924     ISO Abbreviation:  Leukemia     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-11-04     Completed Date:  1998-11-04     Revised Date:  2013-03-04    
Medline Journal Info:
Nlm Unique ID:  8704895     Medline TA:  Leukemia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  S7-12     Citation Subset:  IM    
Affiliation:
Howard Hughes Medical Institute, Brigham & Women's Hospital, Harvard Institutes of Medicine, Boston, MA 02115, USA.
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MeSH Terms
Descriptor/Qualifier:
Humans
Leukemia / genetics*
Translocation, Genetic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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