Document Detail


Molecular genetics of B-precursor acute lymphoblastic leukemia.
MedLine Citation:
PMID:  23023711     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
B-precursor acute lymphoblastic leukemia (B-ALL) is the most common childhood tumor and the leading cause of cancer-related death in children and young adults. The majority of B-ALL cases are aneuploid or harbor recurring structural chromosomal rearrangements that are important initiating events in leukemogenesis but are insufficient to explain the biology and heterogeneity of disease. Recent studies have used microarrays and sequencing to comprehensively identify all somatic genetic alterations in acute lymphoblastic leukemia (ALL). These studies have identified cryptic or submicroscopic genetic alterations that define new ALL subtypes, cooperate with known chromosomal rearrangements, and influence prognosis. This article reviews these advances, discusses results from ongoing second-generation sequencing studies of ALL, and highlights challenges and opportunities for future genetic profiling approaches.
Authors:
Charles G Mullighan
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-10-01
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  122     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-01     Completed Date:  2013-02-01     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3407-15     Citation Subset:  AIM; IM    
Affiliation:
Department of Pathology, St. Jude Children’s Research Hospital, Memphis, Tennessee 38105, USA. charles.mullighan@stjude.org
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Animals
B-Lymphocytes / pathology
Cell Lineage
Child
Clone Cells / pathology
Gene Expression Profiling
Genetic Predisposition to Disease
Hematopoietic Stem Cells / pathology
Humans
Mice
Mice, Knockout
Neoplasm Proteins / genetics*,  physiology
Oncogene Proteins, Fusion / genetics,  physiology
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / classification,  epidemiology,  genetics*,  physiopathology
Prognosis
Risk
Translocation, Genetic
Chemical
Reg. No./Substance:
0/Neoplasm Proteins; 0/Oncogene Proteins, Fusion
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The molecular basis of T cell acute lymphoblastic leukemia.
Next Document:  Molecular pathogenesis of mantle cell lymphoma.