Document Detail

Molecular genetics of B-precursor acute lymphoblastic leukemia.
MedLine Citation:
PMID:  23023711     Owner:  NLM     Status:  MEDLINE    
B-precursor acute lymphoblastic leukemia (B-ALL) is the most common childhood tumor and the leading cause of cancer-related death in children and young adults. The majority of B-ALL cases are aneuploid or harbor recurring structural chromosomal rearrangements that are important initiating events in leukemogenesis but are insufficient to explain the biology and heterogeneity of disease. Recent studies have used microarrays and sequencing to comprehensively identify all somatic genetic alterations in acute lymphoblastic leukemia (ALL). These studies have identified cryptic or submicroscopic genetic alterations that define new ALL subtypes, cooperate with known chromosomal rearrangements, and influence prognosis. This article reviews these advances, discusses results from ongoing second-generation sequencing studies of ALL, and highlights challenges and opportunities for future genetic profiling approaches.
Charles G Mullighan
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-10-01
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  122     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-01     Completed Date:  2013-02-01     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3407-15     Citation Subset:  AIM; IM    
Department of Pathology, St. Jude Children’s Research Hospital, Memphis, Tennessee 38105, USA.
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MeSH Terms
B-Lymphocytes / pathology
Cell Lineage
Clone Cells / pathology
Gene Expression Profiling
Genetic Predisposition to Disease
Hematopoietic Stem Cells / pathology
Mice, Knockout
Neoplasm Proteins / genetics*,  physiology
Oncogene Proteins, Fusion / genetics,  physiology
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / classification,  epidemiology,  genetics*,  physiopathology
Translocation, Genetic
Reg. No./Substance:
0/Neoplasm Proteins; 0/Oncogene Proteins, Fusion

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