Document Detail

Molecular and genetic studies on the euchromatin-heterochromatin transition region of the X chromosome of Drosophila melanogaster. 1. A cloned entry point near to the uncoordinated (unc) locus.
MedLine Citation:
PMID:  6201325     Owner:  NLM     Status:  MEDLINE    
A recombinant Charon 4 bacteriophage has been isolated on the basis of RNAs which are enriched in the head of the adult Drosophila melanogaster and hence are likely to be of neural origin. The cloned insert maps to the near vicinity of the uncoordinated locus in polytene chromosome band 19E8. This band is within the transition zone between the euchromatic and heterochromatic regions of the X chromosome, a region which has been well characterized cytogenetically. The insert contains both repetitious and low copy number sequences, some of which vary extensively in both frequency and restriction fragment size between different laboratory strains. One particular family of moderately repeated sequences occurs predominantly in divisions 19 and 20 of the X chromosome and perhaps the distally located X heterochromatin. The molecular landscape surrounding the initial entry point contains many repeated sequences and is thus unlike those observed in most published chromosomal walks. The possible significance of the presence of repeated families in the distinct properties of this region are discussed.
G L Miklos; M J Healy; P Pain; A J Howells; R J Russell
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chromosoma     Volume:  89     ISSN:  0009-5915     ISO Abbreviation:  Chromosoma     Publication Date:  1984  
Date Detail:
Created Date:  1984-06-11     Completed Date:  1984-06-11     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  2985138R     Medline TA:  Chromosoma     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  218-27     Citation Subset:  IM    
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MeSH Terms
Bacteriophage lambda
Chromatin / genetics*
Chromosome Mapping*
Cloning, Molecular
DNA / genetics
Drosophila melanogaster / genetics*
Heterochromatin / genetics*
Nucleic Acid Hybridization
RNA / genetics
Repetitive Sequences, Nucleic Acid
X Chromosome / ultrastructure*
Reg. No./Substance:
0/Chromatin; 0/Euchromatin; 0/Heterochromatin; 63231-63-0/RNA; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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