| Molecular & genetic factors contributing to insulin resistance in polycystic ovary syndrome. | |
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MedLine Citation:
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PMID: 20571162 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Polycystic ovary syndrome (PCOS) is the most common endocrine disorder of unknown etiology. Insulin resistance is very common and plays a central pathogenic role in PCOS. During last decade several studies have been conducted to understand the mechanisms contributing to the state of insulin resistance and insulin-induced hyperandrogenemia in PCOS. Insulin signaling pathways have been dissected in different insulin responsive tissues such as skeletal muscles, adipose tissues, fibroblasts as well as ovaries to elucidate the mechanism. These studies suggest a post receptor signaling defect where metabolic action of insulin is affected but not the steroidogenic and mitogenic actions. Despite advancement in these studies gaps exist in our understanding of the mechanism of insulin resistance as well as insulin- induced steroidogenesis in PCOS. The syndrome is now considered as a complex multigenic disorder. Efforts are ongoing to dissect the variants of genes from multiple logical pathways which are involved in pathophysiology of the syndrome. But still today no gene has been emerged as universally accepted susceptibility gene for PCOS. This review briefly describes the lacunae along with the current status of molecular events underlying insulin resistance and the contribution of insulin signaling pathway genes in pathogenesis of PCOS along with future researchable areas. |
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Authors:
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Sarbani Mukherjee; Anurupa Maitra |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The Indian journal of medical research Volume: 131 ISSN: 0971-5916 ISO Abbreviation: Indian J. Med. Res. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-23 Completed Date: 2010-09-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374701 Medline TA: Indian J Med Res Country: India |
Other Details:
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Languages: eng Pagination: 743-60 Citation Subset: IM |
Affiliation:
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Department of Molecular Endocrinology, National Institute for Research in Reproductive Health (ICMR) Mumbai, India. mukherjees@nirrh.res.in |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipocytes
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cytology,
metabolism Adipose Tissue / metabolism Animals Female Fibroblasts / cytology, physiology Genetic Variation Humans Hyperandrogenism / complications, physiopathology Insulin / metabolism Insulin Resistance / physiology* Muscle, Skeletal / cytology, physiology Polycystic Ovary Syndrome / etiology, physiopathology* Signal Transduction / physiology |
| Chemical | |
Reg. No./Substance:
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11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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