| Molecular genetic evidence supporting the neoplastic nature of stromal cells in 'fibrosis' after chemotherapy for testicular germ cell tumours. | |
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MedLine Citation:
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PMID: 17634958 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A residual retroperitoneal mass containing only fibrosis and necrosis is present in 40-52% of patients with advanced testicular germ cell tumours after chemotherapy. The biological nature and genetic characteristics of the stromal cells in these residual masses have not been adequately investigated. Laser-microdissected stromal cells from 27 patients who underwent retroperitoneal lymph node dissection after chemotherapy for metastatic testicular germ cell tumour were analysed. Allelic loss in the stromal cells of fibrosis was present at one or more of the ten microsatellite DNA loci examined in 23 (85%) of the cases. Chromosome arm 12p anomalies, the hallmark of germ cell neoplasia, were present in nine (33%) cases. The high frequency of allelic losses and chromosome arm 12p anomalies in the stromal cells from residual retroperitoneal fibrous masses after chemotherapy for testicular germ cell tumours suggests that the stromal cells are derived from the same tumour progenitor cells as the pre-existing metastatic germ cell tumour. |
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Authors:
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L Cheng; S Zhang; M Wang; D D Davidson; M J Morton; J Huang; S Zheng; T D Jones; S D Beck; R S Foster |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of pathology Volume: 213 ISSN: 0022-3417 ISO Abbreviation: J. Pathol. Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-08-16 Completed Date: 2007-12-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0204634 Medline TA: J Pathol Country: England |
Other Details:
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Languages: eng Pagination: 65-71 Citation Subset: IM |
Affiliation:
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Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA. lcheng@iupui.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Antineoplastic Combined Chemotherapy Protocols / therapeutic use Chromosome Aberrations Combined Modality Therapy Fibrosis Humans In Situ Hybridization, Fluorescence Loss of Heterozygosity Lymph Node Excision Lymphatic Metastasis Male Microdissection Microsatellite Repeats / genetics Microscopy, Confocal Necrosis Neoplasms, Germ Cell and Embryonal / genetics*, pathology, therapy Orchiectomy Stromal Cells / metabolism, pathology* Testicular Neoplasms / genetics*, pathology, therapy |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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