Document Detail

Molecular genetic alterations in gliomatosis cerebri: what can we learn about the origin and course of the disease?
MedLine Citation:
PMID:  16222524     Owner:  NLM     Status:  MEDLINE    
Gliomatosis cerebri (GC) is a neuroepithelial neoplasm with extensive infiltration of large parts of the brain. Recent data showing the involvement of TP53 mutation or nuclear protein accumulation in some cases have linked the astrocytic phenotype of the tumor cells to TP53 alterations frequently found in common astrocytomas. However, the frequency of these alterations is low, and other molecular genetic changes have been only rarely identified. Those found in common high-grade astrocytomas and glioblastomas are usually missing in GC. The distribution of TP53 point mutations, as well as non-coding polymorphic markers and some cytogenetic data, support a monoclonal origin in some cases, and are at least compatible with it in most cases, while no conclusive data suggesting a polyclonal origin have been reported. This raises the question of mechanisms responsible for the enhanced infiltrative potential of the tumor cells in this disease, which have not yet been identified.
Christian Mawrin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2005-10-13
Journal Detail:
Title:  Acta neuropathologica     Volume:  110     ISSN:  0001-6322     ISO Abbreviation:  Acta Neuropathol.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-12     Completed Date:  2006-05-05     Revised Date:  2007-11-09    
Medline Journal Info:
Nlm Unique ID:  0412041     Medline TA:  Acta Neuropathol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  527-36     Citation Subset:  IM    
Department of Neuropathology, Otto-von-Guericke-University, Leipziger Strasse 44, 39120, Magdeburg, Germany.
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MeSH Terms
Brain Neoplasms / classification*,  genetics*,  pathology
Genes, p53
Molecular Biology
Neoplasm Invasiveness / genetics*,  pathology
Neoplasms, Neuroepithelial / classification*,  genetics*,  pathology
Tumor Markers, Biological
Reg. No./Substance:
0/Tumor Markers, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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