| Molecular features of astrovirus associated with a gastroenteritis outbreak in an aged-care centre. | |
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MedLine Citation:
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PMID: 17203286 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The study presented here was conducted in order to gain a better understanding of the role of astroviruses (AsVs) in outbreaks of gastroenteritis among the elderly. This report is the first to provide detailed information on the molecular characteristics of an AsV causing an outbreak in an aged-care centre and is the first to clearly establish that individuals infected in such an outbreak were, in fact, elderly. The outbreak under investigation took place in Victoria, Australia, in October 2005. Twelve individuals (mean age +/- standard deviation [SD] 85.5 +/- 12.3 years) became ill during the outbreak from a total population of 86 susceptible residents. The mean duration (+/-SD) of illness was 2.3 +/- 1.6 days; symptoms included diarrhoea, abdominal pain, nausea and headache. No bacterial pathogens were detected. AsV was identified in five faecal specimens using electron microscopy and reverse transcription-polymerase chain reaction methodologies; no other gastroenteritis virus was detected. Nucleotide sequence analysis indicated the AsV identified could be assigned to the 1d lineage of AsV serotype 1 and that the AsV was not a recombinant form. The findings, taken together with previous work, indicate the AsV serotype most commonly associated with gastroenteritis outbreaks among the elderly is serotype 1 AsV. |
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Authors:
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J A Marshall; L D Bruggink; K Sturge; N Subasinghe; A Tan; G G Hogg |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology Volume: 26 ISSN: 0934-9723 ISO Abbreviation: Eur. J. Clin. Microbiol. Infect. Dis. Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2007-01-11 Completed Date: 2007-03-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8804297 Medline TA: Eur J Clin Microbiol Infect Dis Country: Germany |
Other Details:
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Languages: eng Pagination: 67-71 Citation Subset: IM |
Affiliation:
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Victorian Infectious Diseases Reference Laboratory, North Melbourne, Victoria, Australia. john.marshall@mh.org.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged, 80 and over Astroviridae Infections / genetics* Australia / epidemiology Disease Outbreaks* Feces / microbiology, virology Female Gastroenteritis / epidemiology*, virology* Homes for the Aged* Humans Infection Control Male Mamastrovirus / classification, genetics*, pathogenicity Middle Aged Nursing Homes* Polymerase Chain Reaction Serotyping |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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