Document Detail

Molecular evolution within the L-malate and L-lactate dehydrogenase super-family.
MedLine Citation:
PMID:  12029364     Owner:  NLM     Status:  MEDLINE    
The NAD(P)-dependent malate (L-MalDH) and NAD-dependent lactate (L-LDH) form a large super-family that has been characterized in organisms belonging to the three domains of life. In the first part of this study, the group of [LDH-like] L-MalDH, which are malate dehydrogenases resembling lactate dehydrogenase, were analyzed and clearly defined with respect to the other enzymes. In the second part, the phylogenetic relationships of the whole super-family were presented by taking into account the [LDH-like] L-MalDH. The inferred tree unambiguously shows that two ancestral genes duplications, and not one as generally thought, are needed to explain both the distribution into two enzymatic functions and the observation of three main groups within the super-family: L-LDH, [LDH-like] L-MalDH, and dimeric L-MalDH. In addition, various cases of functional changes within each group were observed and analyzed. The direction of evolution was found to always be polarized: from enzymes with a high stringency of substrate recognition to enzymes with a broad substrate specificity. A specific phyletic distribution of the L-LDH, [LDH-like] L-MalDH, and dimeric L-MalDH over the Archaeal, Bacterial, and Eukaryal domains was observed. This was analyzed in the light of biochemical, structural, and genomic data available for the L-LDH, [LDH-like] L-MalDH, and dimeric L-MalDH. This analysis led to the elaboration of a refined evolutionary scenario of the super-family, in which the selection of L-LDH and the fate of L-MalDH during mitochrondrial genesis are presented.
Dominique Madern
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of molecular evolution     Volume:  54     ISSN:  0022-2844     ISO Abbreviation:  J. Mol. Evol.     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-05-24     Completed Date:  2002-10-22     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0360051     Medline TA:  J Mol Evol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  825-40     Citation Subset:  IM    
Laboratoire de Biophysique Moléculaire, Institut de Biologie Structurale CEA-CNRS-UJF, 41 rue Jules Horowitz, 38027 Grenoble Cedex 1, France.
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MeSH Terms
Escherichia coli / enzymology
Evolution, Molecular*
Geobacillus stearothermophilus / enzymology
Haloarcula marismortui / enzymology
L-Lactate Dehydrogenase / chemistry,  classification,  genetics*
Malate Dehydrogenase / chemistry,  classification,  genetics*
Sequence Alignment
Reg. No./Substance:
EC Dehydrogenase; EC Dehydrogenase

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