| Molecular evolution of functional nucleic acids with chemical modifications. | |
| | |
MedLine Citation:
|
PMID: 20714306 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Nucleic acids are attractive materials for creating functional molecules that have applications as catalysts, specific binders, and molecular switches. Nucleic acids having such functions can be obtained by random screening, typically using in vitro selection methods. These methods have helped explore the potential abilities of nucleic acids and steadily contributed to their evolution, i.e., creation of RNA/DNA enzymes, aptamers, and aptazymes. Chemical modification would be a key means to further increase their performance, e.g., expansion of function diversity, enhancement of activity, and improvement of biostability for biological use. Indeed, in the past two decades, random screening involving chemical modification, post-SELEX chemical modification, and rational design methods have been advanced, and combining and integrating these methods may produce a new class of functional nucleic acids. This review focuses on the effectiveness of chemical modifications on the evolution of nucleic acids as functional molecules and the outlook for related technologies. |
| | |
Authors:
|
Masayasu Kuwahara; Naoki Sugimoto |
Related Documents
:
|
14620816 - Soluble sunscreens fully protect e. coli from disinfection by electrohydraulic discharges. 20186496 - Circulating nucleic acids as a new diagnostic tool. 8422966 - 5s rrna modification in the hyperthermophilic archaea sulfolobus solfataricus and pyrod... 19652346 - Crystallization and x-ray diffraction analysis of an 'all-locked' nucleic acid duplex d... 12481086 - Molecular analysis of a bifunctional fatty acid conjugase/desaturase from tung. implica... 5350326 - Genetic coding: oligonucleotide coding for first six amino acid residues of the coat pr... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-08-09 |
Journal Detail:
|
Title: Molecules (Basel, Switzerland) Volume: 15 ISSN: 1420-3049 ISO Abbreviation: Molecules Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-08-17 Completed Date: 2010-12-03 Revised Date: 2010-12-15 |
Medline Journal Info:
|
Nlm Unique ID: 100964009 Medline TA: Molecules Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 5423-44 Citation Subset: IM |
Affiliation:
|
Chemistry Laboratory of Artificial Biomolecules (CLAB), Graduate School of Engineering, Gunma University, Kiryu, Gunma, Japan. kuwahara@chem-bio.gunma-u.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aptamers, Nucleotide
/
chemistry Base Sequence Directed Molecular Evolution* Enzymes / metabolism Molecular Sequence Data Nucleic Acids / chemical synthesis*, chemistry* SELEX Aptamer Technique |
| Chemical | |
Reg. No./Substance:
|
0/Aptamers, Nucleotide; 0/Enzymes; 0/Nucleic Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Using topological indices to predict anti-Alzheimer and anti-parasitic GSK-3 inhibitors by multi-tar...
Next Document: Antioxidant activity of butyl- and phenylstannoxanes derived from 2-, 3- and 4-pyridinecarboxylic ac...