Document Detail


Molecular evolution of UCP1 and the evolutionary history of mammalian non-shivering thermogenesis.
MedLine Citation:
PMID:  19128480     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Uncoupling protein 1 (UCP1) is a mitochondrial anion carrier, expressed in brown adipose tissue (BAT) of Eutherians. UCP1 is responsible for uncoupling mitochondrial proton transport from the production of ATP, thereby dissipating heat; it is essential for non-shivering thermogenesis (NST) in mammalian BAT. UCP1 orthologs have been identified in non-Eutherian mammals, fish and amphibians. Yet, UCP1 has a unique function in Eutherians in that it is necessary in the production of heat (NST). As such, this study aims to determine the evolutionary mode of UCP1 in Eutherians, where there is clear evidence of UCP1-dependent NST in BAT.
RESULTS: Models of adaptive evolution through phylogenetic analysis of amino acid sequences by maximum likelihood were implemented to determine the mode of UCP1 protein evolution in Eutherians. An increase in the rate of amino acid substitutions on the branch leading to Eutherians is observed, but is best explained by relaxed constraints, not positive selection. Further, evidence for branch and site heterogeneity in selection pressures, as well as divergent selection pressures between UCP1 and its paralogs (UCP2-3) is observed.
CONCLUSION: We propose that the unique thermogenic function of UCP1 in Eutherians may be best explained by neutral processes. Along with other evidence, this suggests that the primary biochemical properties of UCP1 may not differ between Eutherians and non-Eutherians.
Authors:
David A Hughes; Martin Jastroch; Mark Stoneking; Martin Klingenspor
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-01-07
Journal Detail:
Title:  BMC evolutionary biology     Volume:  9     ISSN:  1471-2148     ISO Abbreviation:  BMC Evol. Biol.     Publication Date:  2009  
Date Detail:
Created Date:  2009-01-16     Completed Date:  2009-01-23     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  100966975     Medline TA:  BMC Evol Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  4     Citation Subset:  IM    
Affiliation:
Max-Planck-Institute for Evolutionary Anthropology, Department of Evolutionary Genetics, Leipzig, Germany. hughes@eva.mpg.de
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MeSH Terms
Descriptor/Qualifier:
Animals
Codon / genetics
Evolution, Molecular*
Genetic Variation
Ion Channels / genetics*
Mammals / classification*
Mitochondrial Proteins / genetics*
Phylogeny
Selection, Genetic
Thermogenesis / genetics*
Chemical
Reg. No./Substance:
0/Codon; 0/Ion Channels; 0/Mitochondrial Proteins; 0/mitochondrial uncoupling protein
Comments/Corrections

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