Document Detail


Molecular evidence for transplacental transmission of Theileria equi from carrier mares to their apparently healthy foals.
MedLine Citation:
PMID:  17601669     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The intra-erythrocytic parasite Theileria equi is one of two tick-transmitted causative agents of equine piroplasmosis. Piroplasms of T. equi can be transmitted across the equine placenta and once a horse is infected, it appears to remain a lifelong carrier, since anti-theilerial drugs suppress but do not eliminate the parasite. Carrier mares may transmit the organism to their offspring and this may result in abortion or neonatal piroplasmosis, but observations by some researchers suggest that foals may be born as carriers yet remain apparently healthy. Using a T. equi-specific oligonucleotide probe, we have determined that transplacental transmission occurs early in equine foetal development and that carrier mares may give birth to healthy carrier foals. Investigation of parasite levels and the effect of maternal colostrum on the newborn suggests that colostral T. equi antibody may act to suppress parasitaemia in the newborn, reducing the incidence of clinical neonatal piroplasmosis.
Authors:
M T E P Allsopp; B D Lewis; B L Penzhorn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-06-29
Journal Detail:
Title:  Veterinary parasitology     Volume:  148     ISSN:  0304-4017     ISO Abbreviation:  Vet. Parasitol.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-06     Completed Date:  2007-10-11     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7602745     Medline TA:  Vet Parasitol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  130-6     Citation Subset:  IM    
Affiliation:
Onderstepoort Veterinary Institute, Private Bag X5, Onderstepoort 0110, South Africa.
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MeSH Terms
Descriptor/Qualifier:
Abortion, Veterinary / parasitology
Animals
Animals, Newborn
Colostrum / immunology
Disease Reservoirs / veterinary
Female
Fetus / parasitology*
Horse Diseases / immunology,  parasitology,  transmission*
Horses
Immunity, Maternally-Acquired*
Infectious Disease Transmission, Vertical / veterinary*
Placenta / parasitology
Pregnancy
Pregnancy Complications, Parasitic / parasitology,  veterinary*
Theileria
Theileriasis / immunology,  parasitology,  transmission*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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