Document Detail


Molecular evidence of tissue renin-angiotensin systems: a focus on the brain.
MedLine Citation:
PMID:  15748539     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hypertension remains one of the largest human health problems, because hypertensive patients carry increased risk for ischemic heart disease, stroke, atherosclerosis, and renal failure. The renin-angiotensin system (RAS) has been intensively investigated for more than 100 years because it is a powerful regulator of blood pressure, and the antihypertensive benefits of RAS inhibitors are very clear. Despite a wealth of clinical and basic studies, the precise mechanisms by which the RAS regulates blood pressure remains incomplete. In this chapter, we review data demonstrating the existence and function of intrinsic tissue RAS, with a primary focus on the brain.
Authors:
Koji Sakai; Curt D Sigmund
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current hypertension reports     Volume:  7     ISSN:  1522-6417     ISO Abbreviation:  Curr. Hypertens. Rep.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-03-07     Completed Date:  2005-08-30     Revised Date:  2006-07-12    
Medline Journal Info:
Nlm Unique ID:  100888982     Medline TA:  Curr Hypertens Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  135-40     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine and Physiology, 3181B Medical Education and Biomedical Research Facility, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
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MeSH Terms
Descriptor/Qualifier:
Angiotensins / metabolism
Animals
Blood Pressure / physiology
Brain / cytology,  metabolism*
Humans
Hypertension / metabolism,  physiopathology
Neuroglia / metabolism
Renin / metabolism
Renin-Angiotensin System / physiology*
Chemical
Reg. No./Substance:
0/Angiotensins; EC 3.4.23.15/Renin

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