Document Detail


Molecular evidence for progression of nephrogenic metaplasia of the urinary bladder to clear cell adenocarcinoma.
MedLine Citation:
PMID:  16360424     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nephrogenic metaplasia or nephrogenic adenoma of the urinary tract may present a diagnostic challenge in surgical pathology practice. Previous case reports suggest the possibility of nephrogenic metaplasia progressing to clear cell adenocarcinoma, but a malignant potential of nephrogenic metaplasia is generally not acknowledged. A case of a 70-year-old female patient with multiple recurrences of nephrogenic metaplasia of the urinary bladder and subsequent development of clear cell adenocarcinoma is described. Immunohistochemical studies help to differentiate the 2 entities. Results of molecular studies, particularly comparative genomic hybridization analysis, suggest clonal evolution of nephrogenic metaplasia to clear cell adenocarcinoma in this case.
Authors:
Arndt Hartmann; Kerstin Junker; Wolfgang Dietmaier; Sören Schröder; Diego Lopez; Ferdinand Hofstädter; Hagen Blaszyk
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2005-11-28
Journal Detail:
Title:  Human pathology     Volume:  37     ISSN:  0046-8177     ISO Abbreviation:  Hum. Pathol.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-12-19     Completed Date:  2006-02-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421547     Medline TA:  Hum Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  117-20     Citation Subset:  IM    
Affiliation:
Institute of Pathology, University of Regensburg, D-93042, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma, Clear Cell / genetics,  metabolism,  pathology*
Adenoma / genetics,  metabolism,  pathology*
Aged
Clone Cells
Cystectomy
DNA, Neoplasm / analysis
Disease Progression
Disease-Free Survival
Female
Humans
Loss of Heterozygosity
Metaplasia / genetics,  metabolism,  pathology
Neoplasm Recurrence, Local
Nucleic Acid Hybridization
Precancerous Conditions / genetics,  metabolism,  pathology*
Tumor Markers, Biological / metabolism
Urethra / surgery
Urinary Bladder / pathology*
Urinary Bladder Neoplasms / genetics,  metabolism,  pathology*
Chemical
Reg. No./Substance:
0/DNA, Neoplasm; 0/Tumor Markers, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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