| Molecular evidence for progression of nephrogenic metaplasia of the urinary bladder to clear cell adenocarcinoma. | |
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MedLine Citation:
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PMID: 16360424 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nephrogenic metaplasia or nephrogenic adenoma of the urinary tract may present a diagnostic challenge in surgical pathology practice. Previous case reports suggest the possibility of nephrogenic metaplasia progressing to clear cell adenocarcinoma, but a malignant potential of nephrogenic metaplasia is generally not acknowledged. A case of a 70-year-old female patient with multiple recurrences of nephrogenic metaplasia of the urinary bladder and subsequent development of clear cell adenocarcinoma is described. Immunohistochemical studies help to differentiate the 2 entities. Results of molecular studies, particularly comparative genomic hybridization analysis, suggest clonal evolution of nephrogenic metaplasia to clear cell adenocarcinoma in this case. |
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Authors:
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Arndt Hartmann; Kerstin Junker; Wolfgang Dietmaier; Sören Schröder; Diego Lopez; Ferdinand Hofstädter; Hagen Blaszyk |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2005-11-28 |
Journal Detail:
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Title: Human pathology Volume: 37 ISSN: 0046-8177 ISO Abbreviation: Hum. Pathol. Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2005-12-19 Completed Date: 2006-02-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9421547 Medline TA: Hum Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 117-20 Citation Subset: IM |
Affiliation:
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Institute of Pathology, University of Regensburg, D-93042, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma, Clear Cell
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genetics,
metabolism,
pathology* Adenoma / genetics, metabolism, pathology* Aged Clone Cells Cystectomy DNA, Neoplasm / analysis Disease Progression Disease-Free Survival Female Humans Loss of Heterozygosity Metaplasia / genetics, metabolism, pathology Neoplasm Recurrence, Local Nucleic Acid Hybridization Precancerous Conditions / genetics, metabolism, pathology* Tumor Markers, Biological / metabolism Urethra / surgery Urinary Bladder / pathology* Urinary Bladder Neoplasms / genetics, metabolism, pathology* |
| Chemical | |
Reg. No./Substance:
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0/DNA, Neoplasm; 0/Tumor Markers, Biological |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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