Document Detail


Molecular events in the cardiomyopathy of sepsis.
MedLine Citation:
PMID:  18256728     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Septic cardiomyopathy is a well-described complication of severe sepsis and septic shock. However, the interplay of its underlying mechanisms remains enigmatic. Consequently, we constantly add to our pathophysiological understanding of septic cardiomyopathy. Various cardiosuppressive mediators have been discovered, as have multiple molecular mechanisms (alterations of myocardial calcium homeostasis, mitochondrial dysfunction, and myocardial apoptosis) that may be involved in myocardial dysfunction during sepsis. Finally, the detrimental roles of nitric oxide and peroxynitrite have been unraveled. Here, we describe our present understanding of systemic, supracellular, and cellular molecular mechanisms involved in sepsis-induced myocardial suppression.
Authors:
Michael A Flierl; Daniel Rittirsch; Markus S Huber-Lang; J Vidya Sarma; Peter A Ward
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Molecular medicine (Cambridge, Mass.)     Volume:  14     ISSN:  1076-1551     ISO Abbreviation:  Mol. Med.     Publication Date:    2008 May-Jun
Date Detail:
Created Date:  2008-05-13     Completed Date:  2008-08-11     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  9501023     Medline TA:  Mol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  327-36     Citation Subset:  IM    
Affiliation:
Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109-0602, United States of America.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiomyopathies / etiology,  metabolism,  pathology*
Humans
Models, Biological
Nitric Oxide / metabolism
Peroxynitrous Acid / metabolism
Sepsis / complications,  metabolism,  pathology*
Shock, Septic / complications,  metabolism,  pathology*
Grant Support
ID/Acronym/Agency:
GM29507/GM/NIGMS NIH HHS; GM61656/GM/NIGMS NIH HHS; HL-31963/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
10102-43-9/Nitric Oxide; 14691-52-2/Peroxynitrous Acid
Comments/Corrections

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