| Molecular events in the cardiomyopathy of sepsis. | |
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MedLine Citation:
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PMID: 18256728 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Septic cardiomyopathy is a well-described complication of severe sepsis and septic shock. However, the interplay of its underlying mechanisms remains enigmatic. Consequently, we constantly add to our pathophysiological understanding of septic cardiomyopathy. Various cardiosuppressive mediators have been discovered, as have multiple molecular mechanisms (alterations of myocardial calcium homeostasis, mitochondrial dysfunction, and myocardial apoptosis) that may be involved in myocardial dysfunction during sepsis. Finally, the detrimental roles of nitric oxide and peroxynitrite have been unraveled. Here, we describe our present understanding of systemic, supracellular, and cellular molecular mechanisms involved in sepsis-induced myocardial suppression. |
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Authors:
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Michael A Flierl; Daniel Rittirsch; Markus S Huber-Lang; J Vidya Sarma; Peter A Ward |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Molecular medicine (Cambridge, Mass.) Volume: 14 ISSN: 1076-1551 ISO Abbreviation: Mol. Med. Publication Date: 2008 May-Jun |
Date Detail:
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Created Date: 2008-05-13 Completed Date: 2008-08-11 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 9501023 Medline TA: Mol Med Country: United States |
Other Details:
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Languages: eng Pagination: 327-36 Citation Subset: IM |
Affiliation:
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Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109-0602, United States of America. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiomyopathies / etiology, metabolism, pathology* Humans Models, Biological Nitric Oxide / metabolism Peroxynitrous Acid / metabolism Sepsis / complications, metabolism, pathology* Shock, Septic / complications, metabolism, pathology* |
| Grant Support | |
ID/Acronym/Agency:
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GM29507/GM/NIGMS NIH HHS; GM61656/GM/NIGMS NIH HHS; HL-31963/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide; 14691-52-2/Peroxynitrous Acid |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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