| Molecular epidemiology of type 1 and 2 dengue viruses in Brazil from 1988 to 2001. | |
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MedLine Citation:
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PMID: 15933777 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dengue is a mosquito-borne viral infection that in recent decades has become a major international public health concern. Epidemic dengue fever reemerged in Brazil in 1981. Since 1990 more than one dengue virus serotype has been circulating in this tropical country and increasing rates of dengue hemorrhagic fever and dengue shock syndrome have been detected every year. Some evidence supports the association between the introduction of a new serotype and/or genotype in a region and the appearance of dengue hemorrhagic fever. In order to study the evolutionary relationships and possible detection of the introduction of new dengue virus genotypes in Brazil in the last years, we analyzed partial nucleotide sequences of 52 Brazilian samples of both dengue type 1 and dengue type 2 isolated from 1988 to 2001 from highly endemic regions. A 240-nucleotide-long sequence from the envelope/nonstructural protein 1 gene junction was used for phylogenetic analysis. After comparing the nucleotide sequences originally obtained in this study to those previously studied by others, and analyzing the phylogenetic trees, we conclude that, after the initial introduction of the currently circulating dengue-1 and dengue-2 genotypes in Brazil, there has been no evidence of introduction of new genotypes since 1988. The increasing number of dengue hemorrhagic fever cases seen in Brazil in the last years is probably associated with secondary infections or with the introduction of new serotypes but not with the introduction of new genotypes. |
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Authors:
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R J Pires Neto; D M Lima; S O de Paula; C M Lima; I M Rocco; B A L Fonseca |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-06-01 |
Journal Detail:
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Title: Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] Volume: 38 ISSN: 0100-879X ISO Abbreviation: Braz. J. Med. Biol. Res. Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-06-03 Completed Date: 2006-01-23 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8112917 Medline TA: Braz J Med Biol Res Country: Brazil |
Other Details:
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Languages: eng Pagination: 843-52 Citation Subset: IM |
Affiliation:
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Departamento de Clínica Médica, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Base Sequence Brazil / epidemiology Dengue / epidemiology* Dengue Virus / classification, genetics* Endemic Diseases* Genetic Variation / genetics* Genotype Humans Molecular Sequence Data Phylogeny RNA, Viral Reverse Transcriptase Polymerase Chain Reaction Serotyping |
| Chemical | |
Reg. No./Substance:
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0/RNA, Viral |
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