Document Detail

Molecular epidemiology of tuberculosis after declining incidence, New York City, 2001-2003.
MedLine Citation:
PMID:  17064454     Owner:  NLM     Status:  MEDLINE    
Tuberculosis incidence in New York City (NYC) declined between 1992 and 2000 from 51.1 to 16.6 cases per 100,000 population. In January 2001, universal real-time genotyping of TB cases was implemented in NYC. Isolates from culture-confirmed tuberculosis cases from 2001 to 2003 were genotyped using IS6110 and spoligotype to describe the extent and factors associated with genotype clustering after declining TB incidence. Of 2408 (91.8%) genotyped case isolates, 873 (36.2%) had a pattern indistinguishable from that of another study period case, forming 212 clusters; 248 (28.4%) of the clustered cases had strains believed to have been widely transmitted during the epidemic years in the early 1990s in NYC. An estimated 27.4% (873 minus 212) of the 2408 cases were due to recent infection that progressed to active disease during the study period. Younger age, birth in the United States, homelessness, substance abuse and presence of TB symptoms were independently associated with greater odds of clustering.
C R Driver; B Kreiswirth; M Macaraig; C Clark; S S Munsiff; J Driscoll; B Zhao
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2006-10-26
Journal Detail:
Title:  Epidemiology and infection     Volume:  135     ISSN:  0950-2688     ISO Abbreviation:  Epidemiol. Infect.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-04-20     Completed Date:  2007-07-03     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  8703737     Medline TA:  Epidemiol Infect     Country:  England    
Other Details:
Languages:  eng     Pagination:  634-43     Citation Subset:  IM    
New York City Department of Health and Mental Hygiene, Bureau of Tuberculosis Control, New York, NY 10007, USA.
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MeSH Terms
Child, Preschool
Infant, Newborn
Middle Aged
Mycobacterium tuberculosis / genetics*
New York City / epidemiology
Risk Factors
Tuberculosis / epidemiology*

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