| Molecular epidemiology of the heterosexual HIV-1 transmission in Kunming, Yunnan Province of China suggests origin from the local IDU epidemic. | |
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MedLine Citation:
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PMID: 16386117 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Molecular epidemiological investigation was conducted among injecting drug users (IDUs) (n = 11) and heterosexuals (n = 15) in Kunming, Yunnan Province of China. HIV-1 genotypes were determined based on the nucleotide sequences of 2.6-kb gag-RT region. The distribution of genotypes among IDUs was as follows: CRF07_BC (5/11) and CRF08_BC (5/11); subtype B' (1/11). Similarly, a majority of Kunming heterosexuals (14/15) were infected with CRF07_BC (4/15), CRF08_BC (6 /15), or subtype B' (4/15), known to predominate among IDUs in China. This contrasts with trends in the coastal regions of China and surrounding southeastern Asian countries, where CRF01_AE predominates among heterosexuals. The heterosexual HIV-1 epidemic in Kunming thus appears to derive from the local IDU epidemic. Of note, subtype B' was the most prevalent strain among heterosexuals before 1997, while CRF07_BC and CRF08_BC became predominant in 2002, indicating a transition of HIV-1 genotype distribution between the early and the more recent samples from Kunming heterosexuals. |
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Authors:
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Xiao-Jie Li; Shigeru Kusagawa; Xueshan Xia; Chaojun Yang; Qianqiu Wang; Yuko Yokota; Yoshimi Hoshina; Toshinari Onogi; Kyoko Nohtomi; Yuko Imamura; Teiichiro Shiino; Rongge Yang; Naoki Yamamoto; Kunlong Ben; Yutaka Takebe |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: AIDS research and human retroviruses Volume: 21 ISSN: 0889-2229 ISO Abbreviation: AIDS Res. Hum. Retroviruses Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2006-01-02 Completed Date: 2006-05-16 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8709376 Medline TA: AIDS Res Hum Retroviruses Country: United States |
Other Details:
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Languages: eng Pagination: 977-80 Citation Subset: IM; X |
Affiliation:
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Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/AB213667; AB213668; AB213669; AB213670; AB213671; AB213672; AB213673; AB213674; AB213675; AB213676; AB213677; AB213678; AB213679; AB213680; AB213681; AB213682; AB213683; AB213684; AB213685; AB213686; AB213687; AB213688; AB213689; AB213690; AB213691; AB213692 |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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China
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epidemiology Female Genes, gag Genotype HIV Infections / epidemiology, transmission*, virology* HIV Reverse Transcriptase / genetics HIV-1 / genetics*, isolation & purification Humans Male Molecular Epidemiology* Molecular Sequence Data Phylogeny Sequence Analysis, DNA Substance Abuse, Intravenous / complications* |
| Chemical | |
Reg. No./Substance:
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EC 2.7.7.49/HIV Reverse Transcriptase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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