Document Detail

Molecular epidemiology of Serratia marcescens outbreaks in two neonatal intensive care units.
MedLine Citation:
PMID:  15484794     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Serratia marcescens can cause serious infections in patients in neonatal intensive care units (NICUs), including sepsis, pneumonia, urinary tract infection, and conjunctivitis. We report the utility of genetic fingerprinting to identify, investigate, and control two distinct outbreaks of S. marcescens.
DESIGN: An epidemiologic investigation was performed to control two clusters of S. marcescens infections and to determine possible routes of transmission. Molecular typing by pulsed-field gel electrophoresis determined the relatedness of S. marcescens strains recovered from neonates, the environment, and the hands of healthcare workers (HCWs).
SETTING: Two geographically distinct level III-IV NICUs (NICU A and NICU B) in two university-affiliated teaching hospitals in New York City.
RESULTS: In NICU A, one major clone, "F," was detected among isolates recovered from four neonates and the hands of one HCW. A second predominant clone, "A," was recovered from four sink drains and one rectal surveillance culture from an asymptomatic neonate. In NICU B, four neonates were infected with clone "D," and three sink drains harbored clone "H." The attributable mortality rate from bloodstream infections was 60% (3 of 5 infants). The antimicrobial susceptibilities of clone F strains varied for amikacin, cefepime, and piperacillin/tazobactam.
CONCLUSIONS: S. marcescens causes significant morbidity and mortality in preterm neonates. Cross-transmission via transient hand carriage of a HCW appeared to be the probable route of transmission in NICU A. Sinks did not harbor the outbreak strains. Antimicrobial susceptibility patterns did not prove to be an accurate predictor of strain relatedness for S. marcescens.
Vladana Milisavljevic; Fann Wu; Elaine Larson; David Rubenstein; Barbara Ross; Lewis M Drusin; Phyllis Della-Latta; Lisa Saiman
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America     Volume:  25     ISSN:  0899-823X     ISO Abbreviation:  Infect Control Hosp Epidemiol     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-10-15     Completed Date:  2004-12-15     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  8804099     Medline TA:  Infect Control Hosp Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  719-21     Citation Subset:  IM; N    
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MeSH Terms
Cross Infection / epidemiology*,  genetics*,  prevention & control
DNA Fingerprinting*
Disease Outbreaks / prevention & control*
Infant, Newborn
Infant, Premature*
Intensive Care Units, Neonatal
Microbial Sensitivity Tests
Serratia Infections / epidemiology*,  genetics*,  prevention & control
Serratia marcescens / genetics*
United States / epidemiology
Grant Support
1 R01 NR05 197/NR/NINR NIH HHS; R01 NR005197/NR/NINR NIH HHS; R01 NR005197-02/NR/NINR NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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