Document Detail


Molecular epidemiology of HIV type 1 subtypes in Rwanda.
MedLine Citation:
PMID:  23458210     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
HIV-1 infection is characterized by genetic diversity, with multiple subtypes and recombinant variants circulating, particularly in sub-Saharan Africa. During the Rwandan genocide, many women experienced multiple rapes and some became HIV-1 infected. We studied plasma and peripheral blood mononuclear cells (PBMCs) from 30 infected women comprising two exposure groups: those with numerous contacts, raped multiple times, and women with one lifetime sexual partner and no history of rape. Population-based sequences from gag, pol, and env genes were analyzed to determine HIV-1 subtypes and intersubtype recombination. Individual plasma-derived variants from 12 women were also analyzed. Subtype A was found in 24/30 (80%), intersubtype recombination (AC and AD) in 4/30 (13%), and subtypes C and D in 1/30 each. In two subjects, the pattern of HIV-1 recombination differed between plasma and PBMC-derived sequences. Intersubtype recombination was common, although there were no significant differences in subtype or recombination rates between exposure groups.
Authors:
Kimdar S Kemal; Kathryn Anastos; Barbara Weiser; Christina M Ramirez; Qiuhu Shi; Harold Burger
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-04-01
Journal Detail:
Title:  AIDS research and human retroviruses     Volume:  29     ISSN:  1931-8405     ISO Abbreviation:  AIDS Res. Hum. Retroviruses     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-13     Completed Date:  2013-08-30     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  8709376     Medline TA:  AIDS Res Hum Retroviruses     Country:  United States    
Other Details:
Languages:  eng     Pagination:  957-62     Citation Subset:  IM; X    
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
HIV Envelope Protein gp120 / genetics
HIV Infections / etiology,  virology*
HIV-1 / genetics*
Humans
Middle Aged
Molecular Epidemiology
Phylogeny
Rape
Rwanda / epidemiology
gag Gene Products, Human Immunodeficiency Virus / genetics
pol Gene Products, Human Immunodeficiency Virus / genetics
Grant Support
ID/Acronym/Agency:
AI-51519/AI/NIAID NIH HHS; D43-TW001403/TW/FIC NIH HHS; DK54615/DK/NIDDK NIH HHS; U01 AI035004/AI/NIAID NIH HHS; U01-AI-34993/AI/NIAID NIH HHS; UO1-AI-35004/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/HIV Envelope Protein gp120; 0/gag Gene Products, Human Immunodeficiency Virus; 0/gp120 protein, Human immunodeficiency virus 1; 0/pol Gene Products, Human Immunodeficiency Virus
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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