Document Detail

Molecular and epidemiological trend of rotavirus infection among infants and children in Japan.
MedLine Citation:
PMID:  19560560     Owner:  NLM     Status:  MEDLINE    
This study investigated the prevalence of group A, B, and C rotavirus (RAV, RBV, RCV) and adenovirus (AdV) infections in infants and children with acute gastroenteritis in Japan from July 2006 to June 2007. A total of 628 fecal specimens collected from infants and children with acute gastroenteritis in five different places (Maizuru, Tokyo, Sapporo, Saga and Osaka) in Japan during the period of July 2006-June 2007 were examined for RAV, RBV, RCV and AdV by RT-multiplex PCR. RAV was further characterized to G-typing and P-typing by RT-multiplex PCR and sequencing method. It was found that 123 (19.6%) fecal specimens were positive for RAV followed by AdV of 4.5%. RBV and RCV could not be detected in this study. Serotype G1 (58.5%) was identified at high levels followed by G9 (20.3%), G2 (11.4%), and G3 (7.3%). P genotyping revealed P[8] as predominant (84.6%) followed by P[4] (13.8%) and P[6] (1.6%). During the 2006/2007 rotavirus season, G1P[8] strains were most common with G9P[8], G2P[4], G3P[8], G1P[4] and G9P[6] also detected. It is clear from this study that RAV is still the cause of diseases in Japan. To our knowledge, this is the first report of RV P[6] strain in humans in Japan.
Shuvra Kanti Dey; Aksara Thongprachum; Yoshimi Ota; Tung Gia Phan; Shuichi Nishimura; Masashi Mizuguchi; Shoko Okitsu; Hiroshi Ushijima
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-06-26
Journal Detail:
Title:  Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases     Volume:  9     ISSN:  1567-7257     ISO Abbreviation:  Infect. Genet. Evol.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-03     Completed Date:  2009-11-06     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  101084138     Medline TA:  Infect Genet Evol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  955-61     Citation Subset:  IM    
Department of Developmental Medical Sciences, Institute of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/FJ713721;  FJ713722;  FJ713723;  FJ713724;  FJ713725;  FJ713726;  FJ713727;  FJ713728;  FJ713729;  FJ713730;  FJ713731;  FJ713732;  FJ713733;  FJ713734;  FJ713735;  FJ713736;  FJ713737;  FJ713738;  FJ713739;  FJ713740;  FJ713741;  FJ713742;  FJ713743
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MeSH Terms
Acute Disease
Adenovirus Infections, Human / epidemiology,  virology
Adenoviruses, Human / isolation & purification
Antigens, Viral / genetics
Capsid Proteins / genetics
Child, Preschool
Feces / microbiology
Gastroenteritis / epidemiology*,  virology*
Japan / epidemiology
Molecular Epidemiology*
Molecular Sequence Data
Rotavirus / classification,  genetics*,  isolation & purification
Rotavirus Infections / epidemiology*,  virology*
Sequence Analysis, RNA
Reg. No./Substance:
0/Antigens, Viral; 0/Capsid Proteins; 0/VP7 protein, Rotavirus

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