| Molecular epidemiologic features of inflammatory breast cancer: a comparison between Egyptian and US patients. | |
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MedLine Citation:
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PMID: 18058225 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Inflammatory breast cancer (IBC) is a lethal form of breast cancer with unknown etiology. A higher frequency of IBC and a more aggressive IBC phenotype was reported in Egypt than in the United States. This difference in disease frequency and presentation might be related to molecular epidemiologic factors. METHODS: We used tumor blocks and demographic, epidemiologic, and clinical data of 48 IBC patients from Egypt and 12 patients from the United States. We counted tumor emboli in tumors before and after immunohistochemical staining with lymphatic vessel endothelial receptor-1 (LYVE-1), and measured the expression of RhoC GTPase protein in the two groups. RESULTS: Erythema, edema, and peau d'orange were found in 77% of the Egyptian patients as compared with 29% found in the US patients (P=0.02). The number of tumor emboli was significantly higher in tumors from Egypt (mean+/-SD, 14.1+/-14.0) than in the tumors from the United States (5.0+/-4.0, P=0.01). The number of tumor emboli in LYVE-1 positive vessels was higher in tumors from Egypt (3.5+/-2.8) than tumors from the United States (1.6+/-0.5, P=0.15). We detected a high level of RhoC in 87% of the tumors from Egypt and 14% of the tumors from the United States (P=0.0003). CONCLUSION: Patients from Egypt have a more aggressive form of IBC than those in the United States. Our analysis of IBC patients shows that distinct molecular phenotypes can be found when these two study populations are compared. Future studies should explore the epidemiologic and environmental exposures and the genetic factors that might lead to the different clinical and molecular features of IBC in patients from these two countries. |
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Authors:
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An-Chi Lo; Celina G Kleer; Mousumi Banerjee; Sherif Omar; Hussein Khaled; Saad Eissa; Ahmed Hablas; Julie A Douglas; Sharon H Alford; Sofia D Merajver; Amr S Soliman |
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Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2007-12-04 |
Journal Detail:
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Title: Breast cancer research and treatment Volume: 112 ISSN: 0167-6806 ISO Abbreviation: Breast Cancer Res. Treat. Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-09-30 Completed Date: 2008-12-10 Revised Date: 2013-06-06 |
Medline Journal Info:
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Nlm Unique ID: 8111104 Medline TA: Breast Cancer Res Treat Country: Netherlands |
Other Details:
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Languages: eng Pagination: 141-7 Citation Subset: IM |
Affiliation:
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Department of Epidemiology, University of Michigan School of Public Health, 109 Observatory Street, Ann Arbor, MI 48109, USA. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Breast Neoplasms / complications, epidemiology*, genetics* Egypt / epidemiology Epidemiologic Studies Female Humans Immunoenzyme Techniques Incidence Inflammation Medical Records Middle Aged Molecular Epidemiology Prognosis Tissue Array Analysis United States / epidemiology Vesicular Transport Proteins / genetics* rho GTP-Binding Proteins / genetics* |
| Grant Support | |
ID/Acronym/Agency:
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5 P30 CA46592/CA/NCI NIH HHS; CA77612/CA/NCI NIH HHS; K07 CA090241-01A2/CA/NCI NIH HHS; K07 CA90241/CA/NCI NIH HHS; P30 CA046592-21S1/CA/NCI NIH HHS; R03 CA117350/CA/NCI NIH HHS; R03 CA117350-01/CA/NCI NIH HHS; R25 CA112383/CA/NCI NIH HHS; R25 CA112383-01A2/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/LYVE1 protein, human; 0/RHOC protein, human; 0/Vesicular Transport Proteins; EC 3.6.5.2/rho GTP-Binding Proteins |
| Comments/Corrections | |
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