Document Detail

Molecular dosimetry of hepatic aflatoxin B1-DNA adducts: linear correlation with hepatic cancer risk.
MedLine Citation:
PMID:  2505337     Owner:  NLM     Status:  MEDLINE    
An analysis of hepatic aflatoxin B1-DNA adduct (HADA) concentrations in rats and trout demonstrated that the hepatic cancer risk was linearly and quantitatively related in both species. Additionally, the adduct-risk correlation for short-term exposure accurately predicted chronic exposure risk in trout. Although rat and trout liver cells differ substantially in their nuclear DNA content, they appeared to experience similar cancer risks at a given HADA concentration. This may indicate that the liver nuclei of both species contain a similar number of an equivalent protooncogene(s). This analysis also provided a possible basis for the use of adduct measurements for estimating human cancer risk. The minimum human virtual safe dose for aflatoxin was estimated to be 0.264 ng/kg/day on the basis of this approach.
D H Bechtel
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Regulatory toxicology and pharmacology : RTP     Volume:  10     ISSN:  0273-2300     ISO Abbreviation:  Regul. Toxicol. Pharmacol.     Publication Date:  1989 Aug 
Date Detail:
Created Date:  1989-10-03     Completed Date:  1989-10-03     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8214983     Medline TA:  Regul Toxicol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  74-81     Citation Subset:  IM    
Best Foods, Division of CPC International, Inc., Union, New Jersey 07083.
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MeSH Terms
Aflatoxin B1
Aflatoxins / toxicity*
DNA / analysis*,  drug effects
Liver Neoplasms / chemically induced*
Risk Factors
Reg. No./Substance:
0/Aflatoxins; 1162-65-8/Aflatoxin B1; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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